Epigenetics in Health and Disease

In this course, students will explore an alternative perspective on genetic regulation beyond basic Mendelian genetics. If we share the same genetic content, why are our cells different, and why do they perform distinct functions? Why do some diseases profoundly affect gene regulation without a genetic mutation to explain them? The epigenome, a dynamic layer of information associated with genetic material (beyond DNA), plays a crucial role in creating genetic diversity. This course will examine epigenetic mechanisms, their regulation, and their impact on various biological layers, from cellular processes to diseases, brain circuits, psychological disorders, and social behavior. While the primary focus will be on human health and disease, students will also explore non-human case studies, investigating a range of organisms, including plants and animals, to demonstrate the diversity and complexity of epigenetic mechanisms.