Molecular Recognition and Signaling in Self and Non-self Interactions

This course will cover cell signaling mechanisms that allow discrimination between self and non-self interactions in various biological contexts. Self/non-self signaling pathways from several model systems will be examined and their relevance to development and defense will be considered. Topics will include signaling in intra- and inter-species reproductive interactions, signaling in the establishment of symbioses, signaling upon predator attack, signaling in pathogen interactions, and co-evolution of pathogenic and resistance effectors. After one introductory lecture/discussion session led by the instructors, the remaining meetings will be student led and will focus on current primary literature. Open to advanced undergraduates with appropriate coursework.