Signal Transduction

This seminar course will provide a broad introduction to basic mechanisms of cell signaling from the extracellular environment to the nucleus of a cell, and to the mechanisms that regulate signal transmission. Topics of discussion will include: processing and modification of signaling molecules; signal recognition/ligand binding; co-receptors and receptor trafficking; intracellular relays; transduction to the nucleus; regulation of signal intensity and duration; feedback controls. Signal transduction pathways from several model systems will be examined and their relevance to development and disease will be considered. Senior undergraduates with permission of the instructors. Enrollment limited to 20.