DNA Damage and Repair

This course analyzes the chemistry of DNA damaging agents and the molecular mechanisms of DNA replication and DNA repair. We will also analyze the mutagenic and toxic consequences of modifications to DNA structure. Specific topics include the reactions of alkylating agents, ultraviolet radiation, and oxidizing radicals with DNA; additionally, chemotherapeutics that modify DNA will be discussed. Multiple cellular repair pathways will be covered including base excision repair, nucleotide excision repair, mismatch repair, and direct reversal. Prerequisites: CHEM 0350 , CHEM 0360 , BIOL 0280 , BIOL 1270 , or by permission.