Methods in Pharmacoepidemiology

This course will cover applications of epidemiological, biostatistical, and other methods to the study of outcomes of medical interventions (drugs, vaccines, biologics, devices, and procedures) in large numbers of people. The course will focus on more advanced study designs (e.g., sequential target trial emulation) and analytic methods (e.g., high-dimensional propensity score estimation). Methods for evaluating the robustness of study results (i.e., sensitivity and stability analyses) will also be discussed. Formal frameworks of causal inference will be used throughout the course and will be applied to substantive topics in pharmacoepidemiology, vaccine epidemiology, and medical device epidemiology. Prerequisites: PHP 2120, PHP 2140, or PHP 2150; and PHP 2507 or 2510; and PHP 2200; and PHP 2508 or PHP 2511; or instructor permission.