Nucleic Acids, DNA Replication, Transcription and RNA Signalling

1 credits · Graduate Programs

Covers the detailed structure and basic biochemical features of DNA, as it is folded and as it functions inside the eukaryotic nucleus. Topics will include how the 2-metre-long human genome is packaged by "chromatin", how transcription factors are able to choose particular DNA sequences and how this choice leads to active transcription of specific genes, how various classes of transcribed RNA are synthesized and processed, how RNAs function as regulatory molecules, and how the entire genome is replicated in eukaryotic cells. Prerequisite(s): Consent of the course co-ordinator. Preference will be given to those in the Biochemistry and Molecular Biology graduate program.