Structural and Computational Biology

3 Units

This course introduces the major techniques used to study high resolution three-dimensional structures of proteins, and their applications to biomedically-relevant problems and drug discovery. The experimental techniques covered include cryo-electron microscopy, X-ray crystallography, and multi-dimensional solution nuclear magnetic resonance (NMR). Computational/bioinformatics topics include nucleotide and amino acid sequence analysis, protein structure analysis and prediction, and structure-based drug design. Principles of these techniques along with impactful biomedical and drug discovery case studies will be discussed. Recommended preparation: BIOC 307 . Offered as BIOC 334 and BIOC 434 . Prereq: BIOL 215 and ( CHEM 223 or CHEM 323 ).