Computational Medicine

12 units · Graduate

Fall: 12 units Modern medical research increasingly relies on the analysis of large patient datasets to enhance our understanding of human diseases. This course will focus on the computational problems that arise from studies of human diseases and the translation of research to the bedside to improve human health. The topics to be covered include computational strategies for advancing personalized medicine, pharmacogenomics for predicting individual drug responses, metagenomics for learning the role of the microbiome in human health, mining electronic medical records to identify disease phenotypes, and case studies in complex human diseases such as cancer and asthma. We will discuss how machine learning methodologies such as regression, classification, clustering, semi-supervised learning, probabilistic modeling, and time-series modeling are being used to analyze a variety of datasets collected by clinicians. Class sessions will consist of lectures, discussions of papers from the literature, and guest presentations by clinicians and other domain experts. Grading will be based on homework assignments and a project. 02-250 is a suggested pre-requisite. Prerequisites: 10-315 or ( 10-601 and 10-401 and 10-701 ) Course Website: https://sites.google.com/view/computationalmedicine/