Medicinal Chemistry and Drug Development

12 units · Graduate

Spring: 12 units Organic chemistry is an intimate part of the drug discovery and design processes in areas that include structure determination (NMR, mass spectrometry), synthesis, and determination of mechanisms of action. Once a promising compound (i.e. a ?lead?) has been identified in the laboratory, it is rarely ready to be used in the clinic. Complications include poor bioavailability, rapid degradation, and off-target effects. Students will learn about lead compound optimization through structural variations, cell-specific targeting and pro-drug strategies. Several examples will be presented to illustrate the role played by organic chemistry in the development of drugs used to treat a range of diseases, including cancer, HIV-AIDS, bacterial infections and heart disease. Prerequisites: 09-220 or 09-218