CHEM 424
Organic Synthesis
Fall 2022
Topics
- Retrosynthetic analysis
- Multistep synthesis design
- Complex molecular targets
- Organic transformations
- Reaction selection
- Total-synthesis planning
Readings
- K. C. Nicolaou and E. J. Sorensen, Classics in Total Synthesis. Wiley-VCH, 1996. ISBN 3527292845.
- Comprehensive Organic Synthesis: Selectivity, Strategy and Efficiency in Modern Organic Chemistry (1991).
- Fieser and Fieser’s Reagents for Organic Synthesis.
- Comprehensive Organic Functional Group Transformations (1995).
- K. C. Nicolaou and T. Montagnon, Molecules That Changed the World. Wiley-VCH, 2008.
- Suggested: K. C. Nicolaou, “The Art and Science of Organic Synthesis at the Dawn of the Twenty-First Century,” Angewandte Chemie International Edition 39 (2000), pp. 44–122.
- Assignment examples: Michael Smith, Organic Synthesis, chapter 14, sample synthesis proposals (first- or second-edition page references supplied in source).
Sources
- Course catalogue ↗2026–2027
- Syllabus or course outline ↗Fall 2022
- Historical Fall 2022 outline. Required-book authors are misspelled “Nicolau, Sorenson” in the source; standard names are normalized here, with the exact ISBN retained. Other books are listed as useful resources.