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CHEM 424

Organic Synthesis

3 credits · Undergraduate

Fall 2022

Topics

  • Retrosynthetic analysis
  • Multistep synthesis design
  • Complex molecular targets
  • Organic transformations
  • Reaction selection
  • Total-synthesis planning

Readings

  • K. C. Nicolaou and E. J. Sorensen, Classics in Total Synthesis. Wiley-VCH, 1996. ISBN 3527292845.
    Required
  • Comprehensive Organic Synthesis: Selectivity, Strategy and Efficiency in Modern Organic Chemistry (1991).
    Recommended / optional / reference
  • Fieser and Fieser’s Reagents for Organic Synthesis.
    Recommended / optional / reference
  • Comprehensive Organic Functional Group Transformations (1995).
    Recommended / optional / reference
  • K. C. Nicolaou and T. Montagnon, Molecules That Changed the World. Wiley-VCH, 2008.
    Recommended / optional / reference
  • Suggested: K. C. Nicolaou, “The Art and Science of Organic Synthesis at the Dawn of the Twenty-First Century,” Angewandte Chemie International Edition 39 (2000), pp. 44–122.
    Listed reading
  • Assignment examples: Michael Smith, Organic Synthesis, chapter 14, sample synthesis proposals (first- or second-edition page references supplied in source).
    Listed reading
Sources