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CHEM 425

Nucleic Acid Chemistry

3 credits · Undergraduate

Winter 2023

Topics

  • Nucleic-acid nomenclature
  • Heterocycle and nucleoside synthesis
  • Solid-phase synthesis
  • Oligonucleotide purification and characterization
  • DNA and RNA structures
  • Antisense, antigene and RNA interference
  • Small-molecule interactions
  • DNA damage and repair

Readings

  • G. Michael Blackburn, Martin Egli, Michael J. Gait and Jonathan K. Watts (eds.), Nucleic Acids in Chemistry and Biology, 4th ed. Royal Society of Chemistry, 2022.
    Recommended / optional / reference
Sources