Cellular and Molecular Microbial Pathogenesis: The Host Pathogen Interplay

3.0 credits · Undergraduate

Understanding the disease state induced by infection with a microbial pathogen requires knowledge of both the infectious agent and the host. This course will integrate the immune response of the host to challenges from medically important pathogens, including viruses, parasites and bacteria, to provide a unified view of microbial pathogenesis. The lectures will integrate concepts from the disciplines of immunology, bacteriology, virology, and parasitology, to cover aspects of host cell biology and the innate and acquired immune responses of the host to infection. A range of medically relevant human and animal pathogens will be detailed, focusing on the host's response to commensalism versus disease, the mechanisms of host invasion, nutrient acquisition, and modulation of the host's immune response. The course will also discuss current disease interventions and the challenges facing antimicrobial therapy and vaccine development.