Macromolecular Structure Determination by X-Ray Crystallography: Principles and Practice

4 credits · Graduate

Theoretical and practical principles of macromolecular X-ray crystallography. Topics covered include crystal symmetry, space group theory and determination, diffraction theory, a practical understanding of crystallization, X-ray intensity data collection and data processing, phase determination, refinement and model validation. Prerequisites: Undergraduate physical chemistry; undergraduate biochemistry; at least one year of calculus. Instructor consent required.