DNA Damage, Repair Hmn Thrpy

1 Credit · Level: Graduate, Undergraduate

DNA is the most important biological macromolecule in the cell. As such, it is the only macromolecule that can be repaired, all others are simply resynthesized. These DNA maintenance pathways are a hotbed of current medical research. Indeed, DNA damage and repair are used in next-generation genome editing (CRISPR/ TALEN/ Zinc finger), cancer therapies (DNA damaging agents) and synthetic lethality (DNA repair inhibitors). The focus of this course will be the current and emerging clinical approaches that use DNA modification for therapeutic advantage. Because of the cutting-edge nature of the subject matter, a series of weekly readings and related current news items will augment lecture material. Pre-requisites: Some familiarity with molecular biology and genetics through either formal coursework or tutorials will be helpful in understanding course.