Genome Insibity Human Diseas

3 Credits · Level: Graduate, Undergraduate

Our genome is subjected to multiple insults from endogenous and exogenous environmental sources that disturb its integrity. Cells have developed surveillance mechanisms that recognize and respond to cell and DNA damage including DNA repair, cell cycle checkpoints, and programmed apoptosis. When these pathways are compromised or disrupted, the individual is at risk for genomic instability that can lead to a number of diseases and conditions, including cancer, neurological degeneration, immunodeficiency, premature aging, developmental defects, and infertility. This course will focus on the topic of genome instability and its relation to human disease, providing background and historical development of studies, and focusing on molecular mechanisms of these pathways while incorporating current developments in these areas.