Immunogenetics:Evo/HumanHealt

2 Credits · Level: Graduate

The course focuses on the evolutionary forces and evolved systems that shape human health. We have inherited sophisticated immune systems developed over multi-million years to meet changing threats to health. Their present form is contingent on many evolutionary acquisitions in the progression from ancient innate recognition systems to the flexible learning associated with adaptive immunity. The basic processes that govern change - mutation, selection, and chance - are explored in detail, and the role and limitations of each in human health are discussed. The evolution of immune systems is studied using comparative approaches, from prokaryotes to modern humans via lampreys, jawed vertebrates, primates, apes, and our close relatives, the Neandertals and Denisovans. Potential selection drivers are investigated, and evidence of selective pressures is identified. The shortcomings of our immune systems are discussed, and the biotechnological approaches now being used to overcome known limitations are explored.