The Chemistry and Biology of Therapeutics

Harvard FAS

This course will cover the chemical and biological principles that govern small molecule therapeutics. We will discuss small molecule conformational analysis, chemical forces that drive small molecule-protein interactions, and small molecule binding to proteins to affect disease states. We will also discuss how protein targets are identified and the frontiers of modern small molecule therapeutics. Protein targets include, but are not limited to kinases, proteases, GTPases,…