Misfolding diseases and the thermodynamics of protein folding

3 Credits.

This class is an overview of protein structure, folding, and interactions, with emphasis of protein misfolding and human disease. Topics include the hydrophobic effect, self assembly, thermodynamics of protein folding, kinetics of protein folding, and protein association. Special emphasis is placed on experimental techniques, including peptide synthesis, peptide separation and purification techniques, UV-vis, CD, fluorescence, calorimetry, mass-spec, etc. Co-listed with EN.510.426