CHEMENG 6T03
Applications of Chemical Engineering in Medicine (Last Offered 2024-25)
2027
Topics
- Unit 1: Biomaterials – Students will be introduced to the major classes of biomaterials —
- metals, ceramics, and polymers — and examine their physical and chemical properties,
- characterization methods, and biomedical applications. They will develop a framework for
- selecting appropriate biomaterials for specific clinical contexts.
- Unit 2: Biological Responses to Biomaterials – Students will investigate how the body
- responds to implanted materials at the molecular and cellular level, tracing the sequence from
- protein adsorption and thrombosis through immune and inflammatory reactions, tissue repair,
- and resolution. They will understand how material properties shape these host responses.
- Unit 3: Tissue Engineering and Biofabrication – Students will explore strategies for
- engineering functional tissues, covering scaffold design and fabrication, cell selection and
- organize within engineered constructs and how these principles translate to practical tissue
- substitutes.
- Unit 4: Tissue Vascularization Strategy – Students will learn why vascularization is a critical
- bottleneck in tissue engineering and examine biological and engineering strategies to promote
- blood vessel formation. Topics include angiogenesis, vasculogenesis, and methods for creating
- perfusable vascular networks that sustain oxygen and nutrient transport.
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- Unit 5: Microphysiological Systems – Students will be introduced to organ-on-a-chip and
Readings
- D. Williams, “Essential Biomaterials Science” (2014)
- S. Ramakrishna, “Biomaterials: a nano approach” (2010)
- J. Park, R.S. Lakes, “Biomaterials: an Introduction” (2007) – available as an e-book
- J. Enderle, S. Blanchard, J. Bronzino “Introduction to Biomedical Engineering” (2005).
- B.D. Ratner, “Biomaterials Science: An Introduction to Materials in Medicine”, 2nd Ed. (2004) – particularly useful for biological response to materials section
- L. Di Silvio (ed.), “Cellular Response to Biomaterials” (2009)
- J.D. Bronzino (ed.), “The Biomedical Engineering Handbook” (1995)
- R. Baker, “Controlled Release of Biologically Active Agents” (1987)
- W. Mark Saltzmann, “Drug Delivery: Engineering Principles for Drug Therapy” (2001)
- D.A. Lauffenburger and J.J. Linderman, “Receptors: Models for Binding, Trafficking and Signaling” (1993).
- D.O. Cooney, “Biomedical Engineering Principles” (1976)
- T.E. Creighton, “Proteins: Structure and Function” (1992)
- A.L. Shrier and T.G. Kaufmann (eds.), “Mass Transfer in Biological Systems” CEP Symposium Series No. 99 (1970)
- R.C. Seagrave, “Biomedical Applications of Heat and Mass Transfer” (1971)
- C.W. Patrick, A.G. Mikos, L.V. McIntire (eds) “Frontiers in Tissue Engineering” (1998)
- R.P. Lanza, R. Langer and W.L. Chick (eds) “Principles of Tissue Engineering” (1997)
- The outline states that no single textbook covers the course.