SKELETAL MUSCLE IN HEALTH AND DISEASE

Topics

• Course intro
• Muscle overview, form meets function
• Muscle cell anatomy & Sarcomere assembly
• Neuromuscular junction, E-C coupling & cross-bridge mechanics
• Muscle/tendon unit, role of ECM
• MIDTERM
• Myosin isoforms and metabolic profiles (fiber types), Size principle for recruitment
• Muscle hypertrophy
• Muscle atrophy
• Muscle stem cells
• Muscle damage & regeneration
• Muscle adaptations to metabolic diseases