Mass Spectrometry

3 credits · Graduate credit

This course is focused on gaining a deep understanding of the physical principles of this technique, including generation and measurement of high vacuum, sample introduction systems, ionization methods, ion optics, mass analysis, ion detection, electronics, and data processing. Methods for tandem mass spectrometry (MS/MS) experiments are also discussed in detail, including collision induced dissociation, surface induced dissociation, photo dissociation, and techniques involving radical ion chemistry, e.g. electron capture and transfer dissociation, as well a implementation of MS/MS on various mass analyzers.