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2.791

Cellular Neurophysiology and Computing

5-2-5 units · Undergraduate

See description under subject 6.4810J. Preference to juniors and seniors.

Fall 2004 · Quantitative Physiology: Cells and Tissues

Topics

  • Introduction to Cellular Transport
  • Review of Differential Equations
  • Macroscopic and Microscopic Laws of Diffusion
  • Continuity and Diffusion Equations
  • Diffusion
  • Diffusion in Cells: Models
  • Diffusion (cont.)
  • Diffusion in Cells: Experiments
  • Osmosis: van Hoff’s Law
  • Diffusion and Osmosis
  • Osmosis in Cells: Equilibrium
  • Osmosis
  • Chemical Transport
  • Four-State Symmetric Carrier Model
  • Osmosis and Carrier Mediated Transport
  • Carrier Models
  • 4-State Model
  • Glucose Regulation
  • Ion Transport: Nernst-Planck Equation
  • Writing a Laboratory Report
  • Ion Transport: Models
  • Ions
  • Ion Transport Models (cont.)
  • Ions (cont.)
  • Active Transport
  • Electrical Properties of Cells
  • Core Conductor Model of Large Cells
  • Core Conductor
  • HH: Space Clamp
  • Core Conductor (cont.)
  • HH: Voltage Clamp
  • HH: Current Clamp
  • Demo: HH Project
  • HH Elec Classroom
  • HH Project
  • HH: Threshold
  • Cable Model
  • HH Elec Classroom (cont.)
  • Cable Model (cont.)
  • Writing an Oral Presentation
  • Myelinated Fibers
  • Saltatory Conduction
  • Patch Clamp
  • Ion Channels: 2-State Models
  • Ion Channels: 4 Gate Model
  • Ion Channels: Gating Currents
  • Ion Channels
  • Ion Channels (cont.)
  • Ion Channels Multi-State Models
  • Breakfast with the Staff

Readings

  • Buy at MIT Press Weiss, Thomas F. Cellular Biophysics: Transport . Vol. 1. Cambridge, MA: MIT Press, 1996. ISBN: 9780262231831. ↗
    Required
  • Buy at MIT Press ———. Cellular Biophysics: Electrical Properties . Vol. 2. Cambridge, MA: MIT Press, 1996. ISBN: 9780262231848. ↗
    Required
  • ses #: L2 · Topics: Macroscopic and Microscopic Laws of Diffusion · READINGS: Weiss. Volume 1: 3.1-3.1.3, 3.2-3.2.2.
    Reading assignment
  • ses #: L3 · Topics: Continuity and Diffusion Equations · READINGS: Weiss. Volume 1: 3.1.4-3.1.5, 3.5-3.5.2.1.
    Reading assignment
  • ses #: L4 · Topics: Diffusion in Cells: Models · READINGS: Weiss. Volume 1: 3.6-3.6.1.2, 3.7-3.7.2.
    Reading assignment
  • ses #: L5 · Topics: Diffusion in Cells: Experiments · READINGS: Weiss. Volume 1: 3.8-3.8.5.
    Reading assignment
  • ses #: L6 · Topics: Osmosis: van Hoff’s Law · READINGS: Weiss. Volume 1: 4.1-4.3.2.3, 4.4-4.5.1.2.
    Reading assignment
  • ses #: L7 · Topics: Osmosis in Cells: Equilibrium · READINGS: Weiss. Volume 1: 4.7-4.7.1.2.
    Reading assignment
  • ses #: L8 · Topics: Chemical Transport · READINGS: Weiss. Volume 1: 4.7.2-Fig. 4.26 (p. 230), Fig. 4.28, 4.8.2-4.8.3, 6.1-6.2.1.4.
    Reading assignment
  • ses #: L9 · Topics: Four-State Symmetric Carrier Model · READINGS: Weiss. Volume 1: 6.4-6.4.1.4.
    Reading assignment
  • ses #: L10 · Topics: Carrier Models · READINGS: Weiss. Volume 1: 6.4.2-6.4.3, 6.6-6.7.4.
    Reading assignment
  • ses #: L11 · Topics: Glucose Regulation · READINGS: Weiss. Volume 1: 7.2.1, 7.2.3, 7.2.4.1, 7.4.
    Reading assignment
  • ses #: L15 · Topics: Ion Transport Models (cont.) · READINGS: Weiss. Volume 1: 7.5.
    Reading assignment
  • ses #: L16 · Topics: Active Transport · READINGS: Weiss. Volume 1: 7.5.
    Reading assignment
  • ses #: L17 · Topics: Electrical Properties of Cells · READINGS: Weiss. Volume 2: Chapter 1.
    Reading assignment
  • ses #: L18 · Topics: Core Conductor Model of Large Cells · READINGS: Weiss. Volume 2: 2.1-2.4.2.
    Reading assignment
  • ses #: L19 · Topics: Core Conductor · READINGS: Weiss. Volume 2: 2.4.3-2.5.
    Reading assignment
  • ses #: L20 · Topics: HH: Space Clamp · READINGS: Weiss. Volume 2: 4.1-4.1.2.3, 4.2-4.2.2.2.
    Reading assignment
  • ses #: L21 · Topics: HH: Voltage Clamp · READINGS: Weiss. Volume 2: 4.2.3-4.2.3.1.
    Reading assignment
  • ses #: L22 · Topics: HH: Current Clamp · READINGS: Weiss. Volume 2: 4.2.3-4.2.3.2.
    Reading assignment
  • ses #: L23 · Topics: Demo: HH Project · READINGS: Weiss. Volume 2: 4.3.
    Reading assignment
  • ses #: L24 · Topics: HH Project · READINGS: Weiss. Volume 2: 4.4.8.
    Reading assignment
  • ses #: L25 · Topics: HH: Threshold · READINGS: Weiss. Volume 2: 4.4.1.
    Reading assignment
  • ses #: L26 · Topics: Cable Model · READINGS: Weiss. Volume 2: 3.1-3.2.1, 3.3-3.4.2.1.
    Reading assignment
  • ses #: L28 · Topics: Writing an Oral Presentation · READINGS: Weiss. Volume 2: 3.4.2.4-3.4.3.1, 3.4.3.3-3.5.
    Reading assignment
  • ses #: L29 · Topics: Myelinated Fibers · READINGS: Weiss. Volume 2: 5.1-5.2.4.4.
    Reading assignment
  • ses #: L30 · Topics: Saltatory Conduction · READINGS: Weiss. Volume 2: 5.3-5.7.
    Reading assignment
  • ses #: L31 · Topics: Patch Clamp · READINGS: Weiss. Volume 2: 6.1-6.1.1, 6.4-6.4.1.5, 6.2-6.2.2, 6.5-p. 407.
    Reading assignment
  • ses #: L32 · Topics: Ion Channels: 2-State Models · READINGS: Weiss. Volume 2: 6.5-p. 407.
    Reading assignment
  • ses #: L33 · Topics: Ion Channels: 4 Gate Model · READINGS: Weiss. Volume 2: p. 407-p. 416.
    Reading assignment
  • ses #: L34 · Topics: Ion Channels: Gating Currents · READINGS: Weiss. Volume 2: 6.3.2-6.3.6.
    Reading assignment
  • ses #: L35 · Topics: Ion Channels Multi-State Models · READINGS: Weiss. Volume 2: 6.6, 6.7.
    Reading assignment
  • Buy at MIT Press Weiss, Thomas F. Cellular Biophysics: Transport . Vol. 1. Cambridge, MA: MIT Press, 1996. ISBN: 9780262231831. ↗
    Listed reading
  • Buy at MIT Press ———. Cellular Biophysics: Electrical Properties . Vol. 2. Cambridge, MA: MIT Press, 1996. ISBN: 9780262231848. ↗
    Listed reading
  • Vander, Arthur J., James H. Sherman, and Dorothy S. Luciano. Human Physiology, The Mechanisms Body Function . New York, NY: McGraw-Hill, 1998. ISBN: 9780070670655.
    Listed reading
  • Aidley, David J. The Physiology of Excitable Cells . 4th ed. Cambridge, UK: Cambridge University Press, 1998. ISBN: 9780521574211.
    Listed reading
  • Kandel, Eric R., James H. Schwartz, and Thomas M. Jessell. Principles of Neural Science . New York, NY: Elsevier, 1991. ISBN: 9780444015624.
    Listed reading

Prerequisites & course information

Same subject as 6.4810J, 9.21[J] , 20.370[J] Subject meets with 2.794[J] , 6.4812J, 9.021[J] , 20.470[J] , HST.541[J] Prereq: ( Physics II (GIR) , 18.03 , and ( 2.005 , 6.2000 , 6.3000 , 10.301 , or 20.110[J] )) or permission of instructor U (Spring) Not offered regularly; consult department 5-2-5 units

Sources