20.110
Thermodynamics of Biomolecular Systems
Equilibrium properties of macroscopic and microscopic systems. Basic thermodynamics: state of a system, state variables. Work, heat, first law of thermodynamics, thermochemistry. Second and third law of thermodynamics: entropy and its statistical basis, Gibbs function. Chemical equilibrium of reactions in gas and solution phase. Macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding cooperativity, solvation, titration of macromolecules.
Fall 2005
Topics
- Introduction to Thermo; 0 th Law; Temperature; Work; Heat
- State Functions, 1 st Law, Paths
- Joule and Joule-Thompson; Heat Capacity
- Reversible and Irreversible Processes
- Thermochemistry
- 2 nd Law; Entropy (Boltzmann and Clausius)
- ΔS for Reversible and Irreversible Processes
- Equilibrium; Maxwell Relations; Free Energy
- Chemical Potential; Phase Equilibrium
- Chemical Equilibrium; Equilibrium Constant
- Standard States; Gibbs-Duhem
- ΔG 0 = -RTlnK; Example
- Boltzmann Distribution
- Thermo and Boltzmann Distribution
- Occupation of States
- Third Law
- Phase Equilibria, Single Component
- Phase Equilibria II; Clausius Clapeyron
- Regular Solutions; Mixing Energy; Mean Fields
- Nonideal Solutions
- Solvation; Colligative Properties
- Osmotic Pressure and Phase Partitioning
- Surface Tension
- Polymer 1 - Freely Jointed Chain
- Polymer 2 - Chain Conformation
- Polymer 3 - Rubber Elasticity
- Electrolyte Solutions
- Electrolytes at Interfaces; Debye Length
- Titration of Polyelectrolytes
- Thermodynamics of DNA Hybridization
- Cooperativity
- Cooperativity, Part 2
- Cooperativity, Part 3
- Driving Forces for Self-Assembly
- Special Topic (Coarse Grain/Monte Carlo Model)
- Course Review and Evaluations
Readings
- Silbey, R., R. Alberty, and M. Bawendi. Physical Chemistry . New York, NY: John Wiley & Sons, 2004. ISBN: 9780471215042.
- Dill, Ken A., and Sarina Bromberg. Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology . New York, NY: Routledge, 2002. ISBN: 9780815320517.
- [SAB] Silbey, R., R. Alberty, and M. Bawendi. Physical Chemistry . New York, NY: John Wiley & Sons, 2004. ISBN: 9780471215042.
- [DB] Dill, Ken A., and Sarina Bromberg. Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology . New York, NY: Routledge, 2002. ISBN: 9780815320517.
- LEC #: 1 · TOPICS: Introduction to Thermo; 0 th Law; Temperature; Work; Heat · READINGS: SAB 1.1-1.4, 1.8-1.9, 2.1
- LEC #: 2 · TOPICS: State Functions, 1 st Law, Paths · READINGS: SAB 2.2-2.6
- LEC #: 3 · TOPICS: Joule and Joule-Thompson; Heat Capacity · READINGS: SAB 2.7-2.9
- LEC #: 4 · TOPICS: Reversible and Irreversible Processes · READINGS: SAB 2.10, 3.1
- LEC #: 5 · TOPICS: Thermochemistry · READINGS: SAB 2.11-2.13
- LEC #: 6 · TOPICS: 2 nd Law; Entropy (Boltzmann and Clausius) · READINGS: SAB 3.2
- LEC #: 7 · TOPICS: ΔS for Reversible and Irreversible Processes · READINGS: SAB 3.3-3.5
- LEC #: 8 · TOPICS: Equilibrium; Maxwell Relations; Free Energy · READINGS: SAB 4.1-4.2, 4.9
- LEC #: 9 · TOPICS: Chemical Potential; Phase Equilibrium · READINGS: SAB 4.3-4.4, 4.6-4.7
- LEC #: 10 · TOPICS: Chemical Equilibrium; Equilibrium Constant · READINGS: SAB 5.1-5.4
- LEC #: 11 · TOPICS: Standard States; Gibbs-Duhem · READINGS: SAB 4.8
- LEC #: 12 · TOPICS: ΔG 0 = -RTlnK; Example · READINGS: SAB 8.1-8.2
- LEC #: 13 · TOPICS: Boltzmann Distribution · READINGS: DB 6
- LEC #: 14 · TOPICS: Thermo and Boltzmann Distribution · READINGS: DB 10 (first half)
- LEC #: 15 · TOPICS: Occupation of States · READINGS: DB 10 (second half)
- LEC #: 16 · TOPICS: Third Law · READINGS: SAB 3.8
- LEC #: 17 · TOPICS: Phase Equilibria, Single Component · READINGS: SAB 6.1-6.2
- LEC #: 18 · TOPICS: Phase Equilibria II; Clausius Clapeyron · READINGS: SAB 6.3
- LEC #: 19 · TOPICS: Regular Solutions; Mixing Energy; Mean Fields · READINGS: DB 15
- LEC #: 21 · TOPICS: Solvation; Colligative Properties · READINGS: DB 16
- LEC #: 22 · TOPICS: Osmotic Pressure and Phase Partitioning · READINGS: DB 16
- LEC #: 23 · TOPICS: Surface Tension · READINGS: DB 14
- LEC #: 24 · TOPICS: Polymer 1 - Freely Jointed Chain · READINGS: DB 31
- LEC #: 25 · TOPICS: Polymer 2 - Chain Conformation · READINGS: DB 31
- LEC #: 26 · TOPICS: Polymer 3 - Rubber Elasticity · READINGS: DB 32
- LEC #: 31 · TOPICS: Cooperativity · READINGS: DB 26
- LEC #: 32 · TOPICS: Cooperativity, Part 2 · READINGS: DB 28
Prerequisites & course information
Same subject as 2.772[J] Prereq: ( Biology (GIR) , Calculus II (GIR) , Chemistry (GIR) , and Physics I (GIR) ) or permission of instructor U (Fall) 5-0-7 units. REST
Sources
- Course catalogue ↗2026–2027
- MIT OpenCourseWare ↗Fall 2005
- MIT OCW syllabus ↗
- MIT OCW calendar ↗
- MIT OCW readings ↗
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.