Macroepidemiology, Population Genetics, and Stem Cell Biology of Human Clonal Diseases

3-0-15 units · Graduate

Studies the logic and technology needed to discover genetic and environmental risks for common human cancers and vascular diseases. Includes an introduction to metakaryotic stem cell biology. Analyzes large, organized historical public health databases using quantitative cascade computer models that include population stratification of stem cell mutation rates in fetal/juvenile tissues and growth rates in preneoplastic colonies and atherosclerotic plaques. Means to test hypotheses (CAST) that certain genes carry mutations conferring risk for common cancers via genetic analyses in large human cohorts. Involves de novo computer modeling of a lifetime disease experience or test of a student-developed hypothesis.