20.310
Molecular, Cellular, and Tissue Biomechanics
Develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels. Students taking graduate version complete additional assignments.
Spring 2015
Topics
- Term Project Group Presentations
- Term Project Group Presentations (cont.)
- Muscle from the Molecular, Cellular and Tissue Perspectives
Readings
- [Phillips] = Phillips, R., J. Kondev, and J. Theriot. Physical Biology of the Cell . Garland Science, 2008. ISBN: 9780815341635.
- [Howard] = Howard, J. Mechanics of Motor Proteins and the Cytoskeleton . Sinauer Associates, 2001. ISBN: 9780878933334.
- [Lodish] = Lodish, H., D. Baltimore, et al. Molecular Cell Biology . W. H. Freeman and Company, 2012. ISBN: 9781464109812.
- Mahadevan. Macromolecular Mechanics. Chapter 3.
- [Dill & Bromberg] Chapter 17.
- [Howard] Chapters 4 and 6.
- [Grodzinsky] Chapter 1, pp. 15–21.
- [Howard] Chapter 5.
- [Grodzinsky] Chapters 7, Section 7.3.
- [Grodzinsky] Chapter 7, Section 7.4.
- [Grodzinsky] Chapter 7, Section 7.5.
- [Grodzinsky] Chapter 7, Section 7.6.
- Kamm. Chapter 2.2: “Mechanics of the Cytoskeleton.” pp. 15–32.
- Kamm. Chapter 2.2: “Mechanics of the Cytoskeleton.” pp. 32–42.
- Boal, D. Mechanics of the Cell . Cambridge University Press, 2001. ISBN: 9780815342120.
- Lodish, H., D. Baltimore, et al. Molecular Cell Biology . W. H. Freeman & Company, 2012. ISBN: 9781464109812.
- Howard, J. Mechanics of Motor Proteins and the Cytoskeleton . Sinauer Associates, 2001. ISBN: 9780878933334.
- Phillips, R., J. Kondev, et al. Physical Biology of the Cell . Garland Science, 2008. ISBN: 9780815341635.
- Nelson, P. Biophysics Chemistry . Wiley-blackwell, 2008. ISBN: 9781405124362.
- Mofrad, M., and R. Kamm. Cytoskeletal Mechanics: Models and Measurements in Cell Mechanics . Cambridge University Press, 2011. ISBN: 9781107648289.
- Mofrad, M., and R. Kamm. Cellular Mechanotransduction: Diverse Perspectives from Molecules to Tissues . Cambridge University Press, 2009. ISBN: 9780521895231.
- Wales, D. J. Energy Landscapes. With Applications to Clusters, Biomolecules, and Glasses . Cambridge University Press, 2004. ISBN: 9780521814157.
Prerequisites & course information
Same subject as 2.797[J] , 3.053[J] , 6.4840J Subject meets with 2.798[J] , 3.971[J] , 6.4842J, 10.537[J] , 20.410[J] Prereq: Biology (GIR) and 18.03 U (Spring) 4-0-8 units
Sources
- Course catalogue ↗2026–2027
- MIT OpenCourseWare ↗Spring 2015
- MIT OCW readings ↗
- MIT OCW calendar ↗
- MIT OCW syllabus ↗
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.