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Molecular Principles of Biomaterials

Graduate · Historical course

Spring 2006

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Readings

  • von Burkersroda, F., L. Schedl, and A. Gopferich. “Why Degradable Polymers Undergo Surface Erosion or Bulk Erosion.” Biomaterials 23, no. 21 (November 2002): 4221-4231.
    Listed reading
  • Young, R. J., and P. A. Lovell, eds. “Structure.” Chapter 4 in Introduction to Polymers. 2nd ed. Boca Raton, FL: CRC Press, 2000. 241-309. ISBN: 9780748757404.
    Listed reading
  • Saltzman, W. Mark, and W. L. Olbricht. “Building Drug Delivery into Tissue Engineering.” Nat Rev Drug Discov 1, no. 3 (March 2002): 177-186.
    Listed reading
  • ———. “Drug Administration and Drug Effectiveness.” Chapter 2 in Drug Delivery: Engineering Principles for Drug Therapy (Topics in Chemical Engineering). New York, NY: Oxford University Press, 2001. ISBN: 9780195085891.
    Listed reading
  • Flory, Paul J. Principles of Polymer Chemistry . Ithaca, NY: Cornell University Press, 1953, pp. 464-469 and pp. 576-581. ISBN: 9780801401343.
    Listed reading
  • ———. Principles of Polymer Chemistry . Ithaca, NY: Cornell University Press, 1953, pp. 495-507. ISBN: 9780801401343.
    Listed reading
  • Ron, E. S., and L. E. Bromberg. “Temperature-responsive Gels and Thermogelling Polymer Matrices for Protein and Peptide Delivery.” Adv Drug Deliv Rev 31 no. 3 (May 4, 1998): 197-221.
    Listed reading
  • Chandler, D. “Interfaces and the Driving Force of Hydrophobic Assembly.” Nature 437, no. 7059 (September 29, 2005): 640-647.
    Listed reading
  • Lustig, Steven R., and Nikolaos A. Peppas. “Solute Diffusion in Swollen Membranes. IX. Scaling Laws for Solute Diffusion in Gels.” Journal of Applied Polymer Science 36, no. 4 (August 5, 1988): 735-747.
    Listed reading
  • Canal, T., and N. A. Peppas. “Correlation between Mesh Size and Equilibrium Degree of Swelling of Polymeric Networks.” J Biomed Mater Res 23, no. 10 (October 1989): 1183-1193.
    Listed reading
  • Hirano, Y., and D. J. Mooney. “Peptide and Protein Presenting Materials for Tissue Engineering.” Advanced Materials 16, no. 1, (January 2004): 17-25.
    Listed reading
  • Discher, D. E., P. Janmey, and Y. L. Wang. “Tissue Cells Feel and Respond to the Stiffness of their Substrate.” Science 310, no. 5751 (November 18, 2005): 1139-1143.
    Listed reading
  • Lodish, Harvey, Arnold Berk, Lawrence Zipursky, Paul Matsudaira, David Baltimore, and James Darnell, eds. “The Extracellular Matrix.” In Molecular Biology of the Cell. 4th ed. New York, NY: W.H. Freeman, October 1999, pp. 1124-1150. ISBN: 9780716737063.
    Listed reading
  • Mann, Stephen. Biomineralization: Principles and Concepts in Bioinorganic Materials Chemistry . New York, NY: Oxford University Press, 2002, chapter 6, pp. 89-102. ISBN: 9780198508823.
    Listed reading
  • Allen, Samuel M., and Edwin L. Thomas. The Structure of Materials (MIT Series in Materials Science and Engineering) . New York, NY: Wiley, 1999, pp. 135-138. ISBN: 9780471000822.
    Listed reading
  • Hammer, Daniel A., and Dennis E. Discher. “Synthetic Cells-Self-Assembling Polymer Membranes and Bioadhesive Colloids_. ” _Annual Review of Materials Research 31 (August 2001): 387-404.
    Listed reading
  • Allen T. M., and P. R Cullis. “Drug Delivery Systems: Entering the Mainstream.” Science 303, no. 5665 (March 19, 2004): 1818-1822.
    Listed reading
  • Stolnik, S., L. Illum, and S. S. Davis. “Long Circulating Microparticulate Drug Carriers.” Advanced Drug Delivery Reviews 16, no. 2 (September 1995): 195-214 (20).
    Listed reading
  • Halperin, A. “Polymer Brushes that Resist Adsorption of Model Proteins: Design Parameters.” Langmuir 15, no. 7 (1999): 2525-2533.
    Listed reading
  • Efremova, Nadezhda V., Bruce Bondurant, David F. O’Brien, and Deborah E. Leckband. “Measurements of Interbilayer Forces and Protein Adsorption on Uncharged Lipid Bilayers Displaying Poly(ethylene glycol) Chains.” Biochemistry 39 no. 12 (2000): 3441-3451.
    Listed reading
  • Plotkin, Stanley A., Walter A. Orenstein, and Paul A. Offit. “The Immunology of Vaccination.” In Vaccines. Philadelphia, PA: Saunders, 2003, pp. 28-39. ISBN: 9780721696881.
    Listed reading
  • Abbas, Abul K., Andrew H. Lichtman, and Jordan S. Pober. “General Properties of Immune Responses.” In Cellular and Molecular Immunology . 4th ed. Philadelphia, PA: W.B. Saunders Company, 2000. pp. 3-16. ISBN: 07216823323.
    Listed reading
Sources