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22.55

Radiation Biophysics

3-0-9 units · Graduate

Provides a background in sources of radiation with an emphasis on terrestrial and space environments and on industrial production. Discusses experimental approaches to evaluating biological effects resulting from irradiation regimes differing in radiation type, dose and dose-rate. Effects at the molecular, cellular, organism, and population level are examined. Literature is reviewed identifying gaps in our understanding of the health effects of radiation, and responses of regulatory bodies to these gaps is discussed. Students taking graduate version complete additional assignments.

Fall 2004 · Principles of Radiation Interactions

Topics

  • Course Intro/Cells and Tissues Overview
  • Radiation Interactions
  • Radiation Interactions (cont.)
  • Radiation Chemistry/LET/Tracks
  • Effects on Chromosomes/DNA
  • Dose Response in Vitro: Cell Survival Curves
  • RBE/Clustered Damage
  • Protons and Alphas of same LET
  • Dose Response in Vivo
  • Chemical Modification of Radiation Response
  • Cell, Tissue and Tumor Kinetics
  • Radiation Therapy: Tumor Radiobiology
  • Radiation Therapy (contd.): Fractionation
  • Acute Effects of Whole Body Exposure
  • Late Effects: Chronic Exposure/Low Doses
  • Radiation Protection/Background Radiation/Radon
  • Alpha Particles/Bystander Effect
  • Microbeams
  • RBE of Diagnostic X Rays
  • BNCT/Other Modalities
  • Space
  • Space (cont.)
  • Oral Term Paper Presentations

Readings

  • Rydberg, Björn, William R. Holley, I. Saira Mian, and Aloke Chatterjee. “Chromatin Conformation in Living Cells: Support for a Zig-Zag Model of the 30 nm Chromatin Fiber.” Journal of Molecular Biology 284 (1998): 71-84.
    Listed reading
  • Holley, W. R., I. S. Mian, S. J. Park, B. Rydberg, and A. Chatterjee. “A Model for Interphase Chromosomes and Evaluation of Radiation-Induced Aberrations.” Radiation Research 158 (2002): 568–580.
    Listed reading
  • Dikomey, E., J. Dahm-Daphi, I. Brammer, R. Martensen, and B. Kaina. “Correlation between Cellular Radiosensitivity and Non-repaired Double-strand Breaks Studied in Nine Mammalian Cell Lines.” International Journal of Radiation Biology 73, no. 3 (1998): 269-278.
    Listed reading
  • Löbrich, M., P. K. Cooper, and B. Rydberg. “Non-random Distribution of DNA Double-strand Breaks Induced by Particle Irradiation.” International Journal of Radiation Biology 70, no. 5 (1996): 493-503.
    Listed reading
  • The chapters in the table below are from: Hall, Eric J. Radiobiology for the Radiologist . 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 9780781726498.
    Listed reading
  • SES #: 2 · TOPICS: Radiation Interactions · READINGS: Chapter 1
    Reading assignment
  • SES #: 4 · TOPICS: Radiation Chemistry/LET/Tracks · READINGS: Chapter 7
    Reading assignment
  • SES #: 5 · TOPICS: Effects on Chromosomes/DNA · READINGS: Chapter 2
    Reading assignment
  • SES #: 6 · TOPICS: Dose Response in Vitro: Cell Survival Curves · READINGS: Chapter 3
    Reading assignment
  • SES #: 9 · TOPICS: Dose Response in Vivo · READINGS: Chapters 18 and 20
    Reading assignment
  • SES #: 10 · TOPICS: Chemical Modification of Radiation Response · READINGS: Chapters 6, 9 and 25
    Reading assignment
  • SES #: 11 · TOPICS: Cell, Tissue and Tumor Kinetics · READINGS: Chapters 4 and 5
    Reading assignment
  • SES #: 13 · TOPICS: Radiation Therapy: Tumor Radiobiology · READINGS: Chapter 21
    Reading assignment
  • SES #: 14 · TOPICS: Radiation Therapy (contd.): Fractionation · READINGS: Chapter 19
    Reading assignment
  • SES #: 15 · TOPICS: Acute Effects of Whole Body Exposure · READINGS: Chapter 8
    Reading assignment
  • SES #: 16 · TOPICS: Late Effects: Chronic Exposure/Low Doses · READINGS: Chapters 10, 11 and 12
    Reading assignment
  • SES #: 17 · TOPICS: Radiation Protection/Background Radiation/Radon · READINGS: Chapter 15
    Reading assignment
  • SES #: 21 · TOPICS: BNCT/Other Modalities · READINGS: Chapters 24, 27 and 28
    Reading assignment
  • Hall, Eric J. Radiobiology for the Radiologist . 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 0781726429.
    Listed reading
  • Turner, J. E. Atoms, Radiation, and Radiation Protection. 2nd ed. New York: J. Wiley, 1995. ISBN: 9780471595816.
    Listed reading
  • Tubiana, M., J. Dutreix, and A. Wambersie. Introduction to Radiobiology. London, New York, Philadelphia: Taylor and Francis, 1990. ISBN: 9780850667455.
    Listed reading
  • Alpen, Edward L. Radiation Biophysics . 2nd ed. San Diego: Academic Press, 1998. ISBN: 9780120530854.
    Listed reading
  • Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell. Molecular Cell Biology. 4th ed. New York: W.H. Freeman and Company, 2003. ISBN: 9780716743668.
    Listed reading

Prerequisites & course information

Same subject as HST.560[J] Subject meets with 22.055 Prereq: Permission of instructor Acad Year 2027-2028: G (Fall) Acad Year 2028-2029: Not offered 3-0-9 units

Sources