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3.051

Biomaterials Design and Development

3-0-9 units · Undergraduate

Explores the molecular design, structure¿property relationships, and performance of a comprehensive range of materials for biomedical applications. Covers metals/ceramics, polymers, protein- and peptide-based materials, natural biomaterials, and biohybrid systems. Emphasizes rational material selection and engineering design based on the chemical, mechanical, and biological requirements of tissues and specific medical applications. Topics include: emerging strategies for designing new materials, understanding material-tissue integration, host immune responses, immunomodulation, mechanobiology, and the development of stimuli-responsive and biomimetic strategies to improve material performance. Project-based, with students developing a biomaterial platform that addresses a critical health challenge. Students taking graduate version complete additional assignments.

Spring 2006 · Materials for Biomedical Applications

This class provides an introduction to the interactions between cells and the surfaces of biomaterials. The course covers: surface chemistry and physics of selected metals, polymers, and ceramics; surface characterization methodology; modification of biomaterials surfaces; quantitative assays of cell behavior in culture; biosensors and microarrays; bulk properties of implants; and acute and chronic response to implanted biomaterials. General topics include biosensors, drug delivery, and tissue engineering.

Readings

  • Many assigned readings are from the course textbook:
    Listed reading
  • Ratner, Buddy D., et al. Biomaterials Science: An Introduction to Materials in Medicine . 2nd ed. Burlington, MA: Academic Press, 2004. ISBN: 9780125824637.
    Listed reading
  • Course Introduction
    Listed reading
  • Whitesides, G. M., and A. P. Wong. “The Intersection of Biology and Materials Science.” MRS Bulletin 31 (2006): 19-27.
    Listed reading
  • Biomaterials Surfaces: Physics
    Listed reading
  • Biomaterials Surfaces: Chemistry
    Listed reading
  • Jacobs, J. J., J. L. Gilbert, and R. M. Urban. “Corrosion of Metal Orthopaedic Implants.” Journal of Bone and Joint Surgery 80A (1998): 268-282.
    Listed reading
  • Biomaterials Surfaces: Chemistry (cont.)
    Listed reading
  • Ikada, Y., and H. Tsuji. “Biodegradable Polyesters for Medical and Ecological Applications.” Macromolecular Rapid Communications 21 (2000): 117-132.
    Listed reading
  • Protein-Surface Interactions
    Listed reading
  • Cell-Surface Interactions: Host Response to Biomaterials
    Listed reading
  • Cell-Surface Interactions: Host Response to Biomaterials (cont.)
    Listed reading
  • Surface Modification Methods
    Listed reading
  • Surface Modification Methods (cont.)
    Listed reading
  • Surface Characterization
    Listed reading
  • Surface Characterization In situ
    Listed reading
  • Quantifying Cell Behavior
    Listed reading
  • Quantifying Cell Behavior (cont.)
    Listed reading
  • Statistical Analysis
    Listed reading
  • Statistical Analysis (cont.)
    Listed reading
  • Biosensors and Diagnostic Devices
    Listed reading
  • Examples: Fiber Optic Biosensors, Nanobarcodes
    Listed reading
  • Drug Delivery: Controlled Release (Dr. Taniguchi)
    Listed reading
  • Drug Delivery: Controlled Release (cont.)
    Listed reading
  • Duncan, Ruth. “The Dawning Era of Polymer Therapeutics.” Nature Reviews Drug Discovery 2 (2003): 347-360.
    Listed reading
  • Biomaterials for Organ Replacement
    Listed reading
  • Tissue Engineering Cell Types
    Listed reading
  • Tissue Engineering (cont.)
    Listed reading
  • Lec #: 24 · TOPICS: FDA Regulatory Issues and Course Evaluations · READINGS: Ratner: Sections 10.1-10.4.
    Reading assignment

Prerequisites & course information

Subject meets with 3.63 Prereq: Biology (GIR) and Chemistry (GIR) U (Fall) 3-0-9 units

Sources