Nanomechanics of Materials and Biomaterials

Readings

• There is no textbook for this course. Reading assignments are distributed to students in a class reader; supplementary papers are also suggested as additional study material.
  Listed reading
• There is no single required textbook for this course. Israelachvili’s 1992 book (as cited in the table) provides a good treatment of some fundamentals, but many reading assignments are from more recent published papers.
  Listed reading
• Feynman, R. P. “ There’s Plenty of Room at the Bottom .” December 29th 1959 Annual meeting of the American Physical Society at the California Institute of Technology (Caltech). ↗
  Listed reading
• Drexler, K. E. “Engines of Construction.” Chapter 1 in Engines of Creation: The Coming Era of Nanotechnology . New York, NY: Doubleday, New York, 1987. ISBN: 9780385199735.
  Listed reading
• “ Nanotechnology: Shaping the World Atom by Atom .” Report by the National Science and Technology Council (NSTC) Committee on Technology The Interagency Working Group on Nanoscience, Engineering and Technology (IWGN) (1999). ↗
  Listed reading
• Shao, J. “Measuring Piconewton Forces and Its Application in Cellular and Molecular Biomechanics.” Advances in Biomechanics (2001): 47-51.
  Listed reading
• Van Vliet, K. J., G. Bao, and S. Suresh. “The Biomechanics Toolbox: Experimental Approaches for Living Cells and Biomolecules.” Acta Materialia 51 (2003): 5881-5905.
  Listed reading
• LEC #: 3 · TOPICS: Additional nanomechanics instrumentation components · READINGS: Heinz, W. F., and J. H. Hoh. “Spatially Resolved Force Spectroscopy of Biological Surfaces using the Atomic Force Microscope.” Tibtech 17 (1999): 143-150.
  Reading assignment
• Associated paper: Pera, I., and J. Fritz. “Sensing Lipid Bilayer Formation and Expansion with a Microfabricated Cantilever Array.” Langmuir 23, no. 3 (January 30, 2007): 1543-7.
  Listed reading
• Binning, G., C. F. Quate, and C. Gerber. “Atomic Force Microscope.” Physical Review Letters 56 (1986): 930-933.
  Listed reading
• Baselt, D. “Atomic Force Microscopy: Measuring Intermolecular Interaction Forces.” California Institute of Technology, 1993 PhD Thesis, NRL code 6177.
  Listed reading
• Karp, G. “Covalent Bonds” (Section 2.1), and “Noncovalent Bonds” (Section 2.2) in Cell and Molecular Biology . 2nd ed. New York, NY: John Wiley and Sons, Inc., 1999. ISBN: 9780471192794.
  Listed reading
• Associated paper: Higgins, M. J., et al. “Structured Water Layers Adjacent to Biological Membranes.” Biophys J 91 (2006): 2532-2542.
  Listed reading
• LEC #: 7 · TOPICS: Single cell mechanics · READINGS: Dao, M., et al. “Mechanics of the Human Red Blood Cell Deformed by Optical Tweezers.” J Mech Phys Solids 53 (2003): 2259-2280.
  Reading assignment
• Associated paper: Suresh, et al. “Connections Between Single-cell Biomechanics and Human Disease States: Gastrointestinal Cancer and Malaria.” Acta Biomaterialia 1 (2005): 15-30.
  Listed reading
• Ashby, M. F., and D. R. H. Jones. Chapter 3 “The Elastic Moduli,” and Chapter 4 “Bonding Between Atoms.” In Engineering Materials 1 - An Introduction to Properties, Applications, and Design . 3rd ed. Burlington MA: Elsevier Butterworth-Heinemann, 2005. ISBN: 9780750663809.
  Listed reading
• Van Vlack, L. H. “Introduction to Materials: Review of Chemical Bonding.” Chapter 2 in Elements of Materials Science and Engineering . 5th ed. Boston, MA: Addison-Wesley, 1985. ISBN: 9780201080865.
  Listed reading
• Israelachvili, J. “Classification of Forces.” Section 2.6 in Intermolecular and Surface Forces . New York, NY: Academic Press, 1992. ISBN: 9780123751812.
  Listed reading
• ———. “Contrasts between Intermolecular, Interparticle, and Intersurface Forces.” Chapter 10 in Intermolecular and Surface Forces .
  Listed reading
• Malescio, G. “Intermolecular Potentials - Past, Present, and Future.” Nature Materials 2 (2003): 501.
  Listed reading
• Associated Paper: Milovic, N. M., et al. “Monitoring of Heparin and its Low-molecular-weight Analogs by Silicon Field Effect.” PNAS 103, no. 36 (2006): 13374-13379.
  Listed reading
• Israelachvili, J. “Contrasts Between Intermolecular, Interparticle, and Intersurface Forces.” Chapter 10 in Intermolecular and Surface Forces .
  Listed reading
• ———. “Van der Waals Forces Between Surfaces: The Force Laws for Bodies of Different Geometries - The Hamaker Constant.” Chapter 11.1 in Intermolecular and Surface Forces . pp. 176-179.
  Listed reading
• “Table 9.1: Hamaker Constant for various materials.” From Freitas, Robert J. Nanomedicine, Volume I: Basic Capabilities . Georgetown, TX: Landes Bioscience, 1999. ( JPG ) ↗
  Listed reading
• LEC #: 11 · TOPICS: Colloids and interparticle potentials · READINGS: Lewis, J. A. “Colloidal Processing of Ceramics.” J Am Ceram Soc 83, no. 10 (2000): 2341-59.
  Reading assignment
• Associated Paper: Briscoe, W. H., et al. “Boundary Lubrication Under Water.” Nature 444 (2006): 191-194.
  Listed reading
• Autumn, K. “How Gecko Toes Stick.” American Scientist 94 (2006): 124-133.
  Listed reading
• Tian, Yu., et al. “Adhesion and Friction in Gecko Toe Attachment and Detachment.” PNAS 103, no. 51 (2006): 19320-5.
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• Israelachvili, J. “Electrostatic Forces Between Surfaces in Liquids.” Chapter 12 in Intermolecular and Surface Forces .
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• Buckwalter, J. A., H. J. Mankin, and A. J. Grodinzinsky. “Articular Cartilage and Osteoarthritis.” AAOS Instructional Course Lectures 54 (2005): 465-480.
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• Buckwalter, J. A., H. J. Mankin, and A. J. Grodinzinsky “Articular Cartilage and Osteoarthritis.” AAOS Instructional Course Lectures 54 (2005): 465-480.
  Listed reading
• Associated Paper: Dean, D., et al. “Compressive Nanomechanics of Opposing Aggrecan Macromolecules.” J Biomech 39 (2006): 2555-2565.
  Listed reading
• Treloar, L. R. G. “The Elasticity of Long Chain Molecules,” and “Non-Gaussian Chain Statistics and Network Theory.” Chapters 3 and 6 in The Physics of Rubber Elasticity . Oxford, UK: Clarendon Press, 1975.
  Listed reading
• Associated Paper: Ng, Laurel, et al. “Nanomechanical Properties of Individual Chondrocytes and Their Developing Growth Factor-stimulated Pericellular Matrix.” J Biomech 40, no. 5 (2007): 1011-1023.
  Listed reading
• Marko, J. F., and E. D. Siggia. “Stretching DNA.” Macromolecules 28 (1995): 8759-8770.
  Listed reading
• Kratky, O. and G. Porod. “X-ray Investigation of Dissolved Chain Molecules.” Recueil des Travaux Chimiques des Pays-Bas et de la Belgique (Recl Trav Chim Pas-Bas) 68 (1949): 1106-1122.
  Listed reading
• LEC #: 18 · TOPICS: Nanomechanics and biocompatibility: Protein - biomaterial interactions, part 2 · READINGS: Same as prior session.
  Reading assignment
• Fixman, M. and J. Kovac. “Polymer Conformational Statistics. III. Modified Gaussian Models of Stiff Chains.” J Chem Phys 58 (1973): 1574-1568.
  Listed reading
• Bouchiat, C., M. D. Wang, J. F. Allemand, T. Strick, S. M. Block, and V. Croquette. “Estimating the Persistence Length of a Worm-Like Chain Molecule from Force-Extension Measurements.” Biophysical Journal 76 (1999): 409-413.
  Listed reading
• Odijk, T. “Stiff Chains and Filaments under Tension.” Macromolecules 28 (1995): 7016-7018.
  Listed reading
• Rief, M., and H. Helmut Grubmuller. “Force Spectroscopy of Single Biomolecules.” ChemPhysChem 3 (2002): 255-261.
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• Fisher, T. E., A. F. Oberhauser, M. Carrion-Vazquez, P. E. Marszalek, and J. M. Fernandez. “The Study of Protein Mechanics With the Atomic Force Microscope.” TIBS 24 (1999): 379-384.
  Listed reading
• Austin, R. H., J. P. Brody, E. C. Cox, T. Duke, and W. Volkmuth. “Stretch Genes.” Physics Today 50 (1997): 32-38.
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• Clausen-Schaumann, H., M. Rief, C. Tolksdorf, and H. E. Gaub. “Mechanical Stability of Single DNA Molecules.” Biophysical Journal 78 (2000): 1997-2007.
  Listed reading
• Smith, B. L., T. E. Schaffer, M. Viani, J. B. Thompson, N. A. Frederick, J. Kindt, A. Belcher, G. D. Stucky, D. E. Morse, and P. K. Hansma. “Molecular Mechanistic Origin of the Toughness of Natural Adhesives, Fibres and Composites.” Nature 399 (1999): 761-763.
  Listed reading
• Van Landingham, M., J. S. Villarubia, W. F. Guthrie, and G. F. Meyers. “Nanoindentation of Polymers: An Overview.” Macromolecular Symposia 167 (2001): 15-43.
  Listed reading
• Associated Paper: Abu-Lail, N. I., et al. “Understanding the Elasticity of Fibronectin Fibrils: Unfolding Strengths of FN-III and GFP Domains Measured by Single Molecule Force Spectroscopy.” Matrix Biology 25 (2006): 175-184.
  Listed reading
• LEC #: 20 · TOPICS: Theoretical aspects of single molecule force spectroscopy: Extensibility and the worm-like chain (WLC) · READINGS: Same as prior session.
  Reading assignment
• Associated Paper: Fantner, G. E., et al. “Sacrificial Bonds and Hidden Length: Unraveling Molecular Mesostructures in Tough Materials.” Biophys J 90 (2006): 1411-1418.
  Listed reading
• Oliver, W. C., and G. M. Pharr. “An Improved Technique for Determining Hardness and Elastic-modulus Using Load and Displacement Sensing Indentation Expermiments.” J Mater Res 7, no. 6 (June 1992): 1564-1583.
  Listed reading
• Sneddon, Ian. “The Relation Between Load and Penetration in the Axisymmetric Boussinesq Problem for a Punch of Arbitrary Profile.” Journal of Engineering Science 3 (1965): 47-57.
  Listed reading
• LEC #: 23 · TOPICS: Nanoindentation 2: Oliver-Pharr method and one literature example: Nacre · READINGS: Bruet, B. J. F., et al. “Nanoscale Morphology and Indentation of Individual Nacre Tablets From the Gastropod Mollusc Trochus Niloticus.” J Mater Res 20, no. 9 (September 2005): 2400-2419.
  Reading assignment
• LEC #: 24 · TOPICS: Intermolecular interactions in motility of a biological spring (Guest lecture by Danielle France, course TA) · READINGS: Mahadevan, L, and P. Matsudaira. “Motility Powered by Supramolecular Springs and Ratchets.” Science 288 (April 7, 2000): 95-99.
  Reading assignment