Biomaterials-Tissue Interactions

Graduate · Historical course

Fall 2009

This course covers the principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.

Readings

This page lists the readings assigned per class session. Chapters from the course textbook are cited as:
Listed reading
[TORA] = Yannas, I. V. Tissue and Organ Regeneration in Adults . New York, NY: Springer, 2001. ISBN: 9780387952147.
Listed reading
LEC #: 1 · TOPICS: Survey of clinical cases of biomaterials-tissue interactions · READINGS: Class notes: “Survey of Clinical Cases of Biomaterials-Tissue Interactions: The Paradigm.” ( PDF ) ↗
Reading assignment
Giancotti, F. G., and E. Ruoslahti. “ Integrin Signaling .” Science 285 (August 13, 1999): 1028-1032. ↗
Listed reading
Ruoslathi, E., and M. D. Pierschbacher. “ New Perspectives in Cell Adhesion: RGD and Integrins .” Science 238, no. 4826 (October 23, 1987): 491-497. ↗
Listed reading
Gehrig, L., and M. I. O’Connor. “Putting Sex in Your Orthopaedic Practice.” AAOS Now , June 2008.
Listed reading
Di Lullo, G. A., et al. “ Mapping the Ligand-binding Sites and Disease-associated Mutations on the Most Abundant Protein in the Human, Type I Collagen .” J Biol Chem 277, no. 6, I (February 8, 2002): 4223-4231. ↗
Listed reading
Emsley, J., et al. “ Structural Basis of Collagen Recognition by Integrin α2β1 .” Cell 101 (March 31, 2000): 47-56. ↗
Listed reading
Knight, C. Graham. “ The Collagen-binding A-domains of Integrins α1β1 and α2β1 Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens .” J Biol Chem 275, no. 1 (January 7, 2000): 35-40. ↗
Listed reading
Darnell, J. E., H. F. Lodish, and D. Baltimore. “Laminin, Fibronectin and Other Multiadhesive Matrix Glycoproteins.” Chapter 23.4 in Molecular Cell Biology . 2nd ed. New York, NY: W. H. Freeman, 1990, pp. 920-924. ISBN: 9780716719816.
Listed reading
LEC #: 6 · TOPICS: ECM does not regenerate spontaneously · READINGS: [TORA], Chapters 1 and 2
Reading assignment
Ratner, B. D. “Surface Properties of Biomaterials.” In Biomaterials Science: An Introduction to Materials . Edited by B. D. Ratner et al. Burlington, MA: Academic Press, 1996, pp. 21-35. ISBN: 9780125824606. [Preview in Google Books ] ↗
Listed reading
Andrade, J. D., ed. Excerpts from “Principles of Protein Adsorption.” Chapter 1 in Surface and Interfacial Aspects of Biomedical Polymers, Vol. 2. Protein Adsorption . New York, NY: Plenum Press, 1985. ISBN: 9780306417412.
Listed reading
[TORA], Chapters 9 and 10
Listed reading
Freyman, T. M., I. V. Yannas, R. Yokoo, and L. J. Gibson. “ Fibroblast Contraction of a Collagen-GAG Matrix .” Biomaterials 22 (2001): 2883-2891. ↗
Listed reading
Freyman, T. M., I. V. Yannas, Y-S. Pek, R. Yokoo, and L. J. Gibson. “ Micromechanics of Fibroblast Contraction of a Collagen-GAG Matrix .” Experimental Cell Research 269 (2001): 140-153. ↗
Listed reading
Freyman, T. M., I. V. Yannas, R. Yokoo, and L. J. Gibson. “ Fibroblast Contractile Force Is Independent of the Stiffness Which Resists the Contraction .” Experimental Cell Research 272 (2002): 153-162. ↗
Listed reading
Dolores, W., et al. “ Cellular and Molecular Composition of Fibrous Capsules Formed Around Silicone Breast Implants with Special Focus on Local Immune Reactions .” Journal of Autoimmunity 23, no. 1 (2004): 81-91. ↗
Listed reading
Gordon, S., and P. R. Taylor. “ Monocyte and Macrophage Heterogeneity .” Nature Reviews Immunology 5 (December 2005): 953-964. ↗
Listed reading
Spector, M., and P. A. Lalor. “ In Vivo Assessment of Tissue Compatibility.” Chapter 5.3 in Biomaterials Science: An Introduction to Materials . Edited by B. D. Ratner, et al. Burlington, MA: Academic Press, 1996, pp. 220-228. ISBN: 9780125824606. [Preview in Google Books ] ↗
Listed reading
Buter, C. E., D. P. Orgill, I. V. Yannas, and C. C. Compton. “ Effect of Keratinocyte Seeding of Collagen-Glycosaminoglycan Membranes on the Regeneration of Skin in a Porcine Model .” Plastic & Recontructive Surgery 101, no. 6 (May 1998): 1572-1579. ↗
Listed reading
LEC #: 18 · TOPICS: In vivo synthesis of skin · READINGS: [TORA], Chapter 5
Reading assignment
[TORA], Chapter 6
Listed reading
Yannas, I. V., M. Zhang, and M. H. Spilker. “ Standardized Criterion to Analyze and Directly Compare Various Materials and Models for Peripheral Nerve Regeneration .” J Biomater Sci, Polymer Edn 18, no. 8 (2007): 943-966. ↗
Listed reading
LEC #: 20 · TOPICS: Rules for synthesis of tissues and organs · READINGS: [TORA], Chapter 7
Reading assignment
Readings from the literature will be assigned for many classes. Selected readings will also be assigned from the course textbook:
Listed reading
Yannas, I. V. Tissue and Organ Regeneration in Adults . New York, NY: Springer, 2001. ISBN: 9780387952147.
Listed reading

Sources

Course catalogue ↗Historical OpenCourseWare
MIT OCW readings ↗
MIT OCW syllabus ↗
Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.