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5.310

Laboratory Chemistry

2-7-3 units. Institute LAB · Undergraduate

Introduces experimental chemistry for students who are not majoring in Course 5. Principles and applications of chemical laboratory techniques, including preparation and analysis of chemical materials, measurement of pH, gas and liquid chromatography, visible-ultraviolet spectrophotometry, infrared spectroscopy, kinetics, data analysis, and elementary synthesis, are described, in addition to experimental design principles. Includes instruction and practice in written and oral communication to multiple audiences. Enrollment limited.

Fall 2019

Topics

  • L1: Introduction to Laboratory Chemistry (JD)
  • L2: Ferrocene (JD)
  • L3: Writing Up the Lab Report (SH)
  • L4: What’s Significant in Laboratory Measurement? Error Analysis (SH)
  • L5: Ellen Swallow Richards, Part 1 (JD)
  • L6: Ellen Swallow Richards, Part 2 (JD)
  • L7: Ellen Swallow Richards, Part 3 (JD)
  • L8: Essential Oils, Part 1 (SH)
  • L9: Essential Oils, Part 2 (SH)
  • L10: Fischer Esterification (SH)
  • L11: Catalase, Part 1 (SH)
  • [No Lecture]
  • L12: Catalase, Part 2 (SH)
  • L13: X-Ray Diffraction Essential Oils (Guest Lecturer: Peter Mueller)
  • L14: Mass Spectroscopy Esterification (JD)
  • L15: NMR Spectroscopy Esterification (Guest Lecturer: John Grimes)
  • L16: Help session for any lecture/lab material
  • L17: Help session for any lecture/lab material
  • L18: Oral Report Guidelines, Part 1
  • L19: Oral Report Workshop, Part 2
  • L20: Help session for any lecture/lab material
  • Student Oral Reports

Readings

  • [MHS] = Mohrig, Alberg, et al. Laboratory Techniques in Organic Chemistry . 4 th ed. W. H. Freeman, 2014. ISBN: 9781464134227.
    Required
  • [SWH] = Skoog, West, et al. Fundamentals of Analytical Chemistry . 9 th ed. Brooks Cole, 2013. ISBN: 9780495558286. [Preview with Google Books ] ↗
    Recommended
  • [S&L] = Skoog, Holler, and Crouch. Principles of Instrumental Analysis . 6 th ed. CL, 2007. ISBN: 9788131525579.
    Recommended
  • [Oxtoby] = Gillis, and Campion. Principles of Modern Chemistry . 7 th ed. Cengage Learning, 2012. ISBN: 9780840049315.
    Recommended
  • [Atkins] = Jones, and Laverman. Chemical Principles: The Quest for Insight . 6 th ed. W. H. Freeman, 2012. ISBN: 9781429288972.
    Recommended
  • [SFH] = Steinfeld, Joesph S. Francisco, and Wiliam L. Hase. Chemical Kinetics and Dynamics . 2 nd ed. Pearson, 1998. ISBN: 9780137371235.
    Recommended
  • [JWZ] = Zubrick. The Organic Chem Lab Survival Manual: A Student’s Guide to Techniques . 10 th ed. Wiley, 2016. ISBN: 9781118875780.
    Recommended
  • [C&G] = Coghill, and Garson, eds. The ACS Style Guide: Effective Communication of Science Information . 3 rd ed. American Chemical Society, 2006. ISBN: 9780841239999.
    Recommended
  • [MHS] Chapter 1: Safety, pp. 3–21.
    Recommended
  • [MHS] Chapter 3: Laboratory Notebook, pp. 32–39.
    Recommended
  • [MHS] Chapter 4: Laboratory Glassware, pp. 44–51.
    Recommended
  • [MHS] Chapter 5: Measuring Mass and Volume & Transfers, pp. 52–72.
    Recommended
  • [MHS] Chapter 6: Heating Methods & Cooling Methods, pp. 73–86.
    Recommended
  • [MHS] Chapter 13: Using the Literature of Organic Chemistry, pp. 501–506.
    Recommended
  • [JWZ] Chapter 13: Buchner Funnels and Filtration, pp. 107–113.
    Recommended
  • [MHS] Chapter 5: Measuring Mass and Volume, pp. 52–64.
    Recommended
  • [SWH] Chapter 20: Standard Reducing Agents, Thiosulfate Solutions, pp. 511–514.
    Recommended
  • [SWH] Chapter 23: Dissolved Oxygen, pp. 681–682.
    Recommended
  • [MHS] Chapter 25: UV & VIS Spectroscopy, pp. 465–475.
    Recommended
  • Michaud, Joy. Chapter 4 in A Citizens Guide to Understanding and Monitoring Lakes and Streams (PDF – 7.4MB) . Puget Sound Water Quality Authority, 1991, pp. 45–58. ↗
    Recommended
  • [Oxtoby] Chapter 20.1–20.2: General Aspects of Molecular Spectroscopy.
    Listed reading
  • [Oxtoby] Chapter 20.5: Excited Electronic States.
    Listed reading
  • [Oxtoby] Chapter 8.5: The Spectrochemical Series.
    Listed reading
  • [Atkins] Chapter: 4.12: Orbitals in Polyatomic Molecules, pp. 139–140.
    Listed reading
  • [Atkins] Chapter: 17.8: The Electronic Structures of Complexes, pp. 749–759.
    Listed reading
  • [SWH] Chapter: 26: Molecular Absorption Spectroscopy, pp. 723–759.
    Listed reading
  • [SWH] Chapter: 25: Instruments for Optical Spectroscopy.
    Recommended
  • [S&L] Chapter 6: Intro to Spectrometric Methods, pp. 132–135, 141–144, and 157–159.
    Recommended
  • [S&L] Chapter 14: Application of UV/VIS spectroscopy, pp. 367–374.
    Recommended
  • [S&L] Chapter 8: Instruments for Optical Spectroscopy, pp. 215–228.
    Recommended
  • [MHS] Chapter 5.5: Measurement Uncertainty & Error Analysis, pp. 64–73.
    Recommended
  • [SWH] Chapter 5: Errors in Chemical Analysis.
    Recommended
  • [SWH] Chapter 6: Random Errors in Chemical Analysis.
    Recommended
  • [SWH] Chapter 7: Statistical Evaluation of Data.
    Recommended
  • [MHS] Chapter 12: Boiling Point & Distillation, pp. 173–205.
    Recommended
  • [MHS] Chapter 6: Heating & Cooling Methods, pp .73–86.
    Recommended
  • [MHS] Chapter 7: Setting Up Organic Reactions, pp. 87–106.
    Recommended
  • [MHS] Chapter 16: Sublimation, pp. 236–239.
    Recommended
  • [MHS] Chapter 5: Transfer of Reagents Using a Syringe, pp. 59–61.
    Recommended
  • [Oxtoby] Chapter 10.6: Phase Diagrams, pp. 462–465.
    Recommended
  • [Atkins] Chapter 10.6: Phase Diagrams, pp. 375–378.
    Recommended
  • [MHS] Chapter 18: Thin-Layer Chromatography, pp. 255–267.
    Recommended
  • [MHS] Chapter 19: Liquid chromatography, pp. 270–291.
    Recommended
  • [Oxtoby] Chapter 14.8: Distribution of a Single Species between Immiscible Phases: Extraction and Separation Processes, pp. 650–654.
    Recommended
  • [MHS] Chapter 12: Boiling Points and Distillation, pp. 173–205.
    Recommended
  • [Oxtoby] Chapter 11.6: Mixtures and Distillation, pp. 499–504.
    Recommended
  • [Atkins] Chapter 10.15: Vapor Pressure Lowering, pp. 392–394.
    Recommended
  • [MHS] Chapter 21: Infrared Spectroscopy, pp. 311–344.
    Recommended
  • [Oxtoby] Chapter 20.3: Vibrations and Rotations of Molecules.
    Recommended
  • [S&L] Chapter 12: Infrared Absorption Spectroscopy.
    Recommended
  • [MHS] Chapter 20: Gas Chromatography, pp. 291–308.
    Recommended
  • [MHS] Chapter 13: Refractometry, pp. 206–211.
    Recommended
  • [MHS] Chapter 17: Optical Activity and Polarimetry, pp. 240–251.
    Recommended
  • [MHS] Chapter 5: Measuring Mass & Volume, Using Pasteur Pipettes, Thermometer Calibration, pp. 52–63.
    Recommended
  • [MHS] Chapter 7: Refluxing a Reaction Mixture, pp. 59–60.
    Recommended
  • [MHS] Chapter 11: Extraction: Separatory Funnel, pp. 113–124.
    Recommended
  • [MHS] Chapter 12: Boiling Point & Distillation, pp. 174–176.
    Recommended
  • [MHS] Chapter 13: Refractive Index, pp. 206–211.
    Recommended
  • [MHS] Chapter 22: Nuclear Magnetic Resonance, pp. 350–405.
    Recommended
  • [MHS] Chapter 24: Mass Spectrometry, pp. 441–462.
    Recommended
  • [Atkins] Chapter 10: Distillation, pp. 404–406.
    Recommended
  • [Atkins] Chapter 10.3: Clausius-Clapeyron Equation, pp. 371–373.
    Recommended
  • [Atkins] Chapter 10.4: Boiling, pp. 373–374.
    Recommended
  • [Atkins] Chapter 20: Esters, pp. 828–829.
    Recommended
  • [MHS] Chapter 25: UV & VIS Spectroscopy, pp. 465–487.
    Recommended
  • [Atkins] Chapter 4.12: Orbitals in Polyatomic Molecules, pp. 139–140.
    Recommended
  • [Atkins] Chapter 17.8: The Electronic Structures of Complexes, pp. 749–759.
    Recommended
  • [SWH] Chapter 26: Molecular Absorption Spectroscopy, pp. 723–759.
    Listed reading
  • [SWH] Chapter 25: Instruments for Optical Spectroscopy.
    Recommended

Prerequisites & course information

Prereq: None. Coreq: 5.12 U (Fall, Spring) 2-7-3 units. Institute LAB

Sources