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5.601

Thermodynamics I

2-0-4 units · Undergraduate

Basic thermodynamics: state of a system, state variables. Work, heat, first law of thermodynamics, thermochemistry. Second and third law of thermodynamics: entropy and free energy, including the molecular basis for these thermodynamic functions. Equilibrium properties of macroscopic systems. Special attention to thermodynamics related to global energy issues and biological systems. Combination of 5.601 and 5.602 counts as a REST subject.

Fall 2005 · Thermodynamics of Biomolecular Systems

Topics

  • Introduction to Thermo; 0 th Law; Temperature; Work; Heat
  • State Functions, 1 st Law, Paths
  • Joule and Joule-Thompson; Heat Capacity
  • Reversible and Irreversible Processes
  • Thermochemistry
  • 2 nd Law; Entropy (Boltzmann and Clausius)
  • ΔS for Reversible and Irreversible Processes
  • Equilibrium; Maxwell Relations; Free Energy
  • Chemical Potential; Phase Equilibrium
  • Chemical Equilibrium; Equilibrium Constant
  • Standard States; Gibbs-Duhem
  • ΔG 0 = -RTlnK; Example
  • Boltzmann Distribution
  • Thermo and Boltzmann Distribution
  • Occupation of States
  • Third Law
  • Phase Equilibria, Single Component
  • Phase Equilibria II; Clausius Clapeyron
  • Regular Solutions; Mixing Energy; Mean Fields
  • Nonideal Solutions
  • Solvation; Colligative Properties
  • Osmotic Pressure and Phase Partitioning
  • Surface Tension
  • Polymer 1 - Freely Jointed Chain
  • Polymer 2 - Chain Conformation
  • Polymer 3 - Rubber Elasticity
  • Electrolyte Solutions
  • Electrolytes at Interfaces; Debye Length
  • Titration of Polyelectrolytes
  • Thermodynamics of DNA Hybridization
  • Cooperativity
  • Cooperativity, Part 2
  • Cooperativity, Part 3
  • Driving Forces for Self-Assembly
  • Special Topic (Coarse Grain/Monte Carlo Model)
  • Course Review and Evaluations

Readings

  • Silbey, R., R. Alberty, and M. Bawendi. Physical Chemistry . New York, NY: John Wiley & Sons, 2004. ISBN: 9780471215042.
    Required
  • Dill, Ken A., and Sarina Bromberg. Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology . New York, NY: Routledge, 2002. ISBN: 9780815320517.
    Required
  • [SAB] Silbey, R., R. Alberty, and M. Bawendi. Physical Chemistry . New York, NY: John Wiley & Sons, 2004. ISBN: 9780471215042.
    Listed reading
  • [DB] Dill, Ken A., and Sarina Bromberg. Molecular Driving Forces: Statistical Thermodynamics in Chemistry and Biology . New York, NY: Routledge, 2002. ISBN: 9780815320517.
    Listed reading
  • LEC #: 1 · TOPICS: Introduction to Thermo; 0 th Law; Temperature; Work; Heat · READINGS: SAB 1.1-1.4, 1.8-1.9, 2.1
    Reading assignment
  • LEC #: 2 · TOPICS: State Functions, 1 st Law, Paths · READINGS: SAB 2.2-2.6
    Reading assignment
  • LEC #: 3 · TOPICS: Joule and Joule-Thompson; Heat Capacity · READINGS: SAB 2.7-2.9
    Reading assignment
  • LEC #: 4 · TOPICS: Reversible and Irreversible Processes · READINGS: SAB 2.10, 3.1
    Reading assignment
  • LEC #: 5 · TOPICS: Thermochemistry · READINGS: SAB 2.11-2.13
    Reading assignment
  • LEC #: 6 · TOPICS: 2 nd Law; Entropy (Boltzmann and Clausius) · READINGS: SAB 3.2
    Reading assignment
  • LEC #: 7 · TOPICS: ΔS for Reversible and Irreversible Processes · READINGS: SAB 3.3-3.5
    Reading assignment
  • LEC #: 8 · TOPICS: Equilibrium; Maxwell Relations; Free Energy · READINGS: SAB 4.1-4.2, 4.9
    Reading assignment
  • LEC #: 9 · TOPICS: Chemical Potential; Phase Equilibrium · READINGS: SAB 4.3-4.4, 4.6-4.7
    Reading assignment
  • LEC #: 10 · TOPICS: Chemical Equilibrium; Equilibrium Constant · READINGS: SAB 5.1-5.4
    Reading assignment
  • LEC #: 11 · TOPICS: Standard States; Gibbs-Duhem · READINGS: SAB 4.8
    Reading assignment
  • LEC #: 12 · TOPICS: ΔG 0 = -RTlnK; Example · READINGS: SAB 8.1-8.2
    Reading assignment
  • LEC #: 13 · TOPICS: Boltzmann Distribution · READINGS: DB 6
    Reading assignment
  • LEC #: 14 · TOPICS: Thermo and Boltzmann Distribution · READINGS: DB 10 (first half)
    Reading assignment
  • LEC #: 15 · TOPICS: Occupation of States · READINGS: DB 10 (second half)
    Reading assignment
  • LEC #: 16 · TOPICS: Third Law · READINGS: SAB 3.8
    Reading assignment
  • LEC #: 17 · TOPICS: Phase Equilibria, Single Component · READINGS: SAB 6.1-6.2
    Reading assignment
  • LEC #: 18 · TOPICS: Phase Equilibria II; Clausius Clapeyron · READINGS: SAB 6.3
    Reading assignment
  • LEC #: 19 · TOPICS: Regular Solutions; Mixing Energy; Mean Fields · READINGS: DB 15
    Reading assignment
  • LEC #: 21 · TOPICS: Solvation; Colligative Properties · READINGS: DB 16
    Reading assignment
  • LEC #: 22 · TOPICS: Osmotic Pressure and Phase Partitioning · READINGS: DB 16
    Reading assignment
  • LEC #: 23 · TOPICS: Surface Tension · READINGS: DB 14
    Reading assignment
  • LEC #: 24 · TOPICS: Polymer 1 - Freely Jointed Chain · READINGS: DB 31
    Reading assignment
  • LEC #: 25 · TOPICS: Polymer 2 - Chain Conformation · READINGS: DB 31
    Reading assignment
  • LEC #: 26 · TOPICS: Polymer 3 - Rubber Elasticity · READINGS: DB 32
    Reading assignment
  • LEC #: 28 · TOPICS: Electrolytes at Interfaces; Debye Length · READINGS: Class notes ↗
    Reading assignment
  • LEC #: 29 · TOPICS: Titration of Polyelectrolytes · READINGS: Class notes ↗
    Reading assignment
  • LEC #: 30 · TOPICS: Thermodynamics of DNA Hybridization · READINGS: Class notes ↗
    Reading assignment
  • LEC #: 31 · TOPICS: Cooperativity · READINGS: DB 26
    Reading assignment
  • LEC #: 32 · TOPICS: Cooperativity, Part 2 · READINGS: DB 28
    Reading assignment

Prerequisites & course information

Prereq: Calculus II (GIR) and Chemistry (GIR) U (Fall, Spring; first half of term) 2-0-4 units

Sources