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6.023

Fields, Forces and Flows in Biological Systems

Undergraduate · Historical course

Spring 2007

This course introduces the basic driving forces for electric current, fluid flow, and mass transport, plus their application to a variety of biological systems. Basic mathematical and engineering tools will be introduced, in the context of biology and physiology. Various electrokinetic phenomena are also considered as an example of coupled nature of chemical-electro-mechanical driving forces. Applications include transport in biological tissues and across membranes, manipulation of cells and biomolecules, and microfluidics.

Readings

  • TY & K: Truskey, G. A., F. Yuan, and D. F. Katz. Transport Phenomena in Biological Systems . East Rutherford, NJ: Prentice Hall, 2003. ISBN: 9780130422040.
    Listed reading
  • H & M : Haus, H. A., and J. R. Melcher. Electromagnetic Fields and Energy . Upper Saddle River, NJ: Prentice Hall, 1989. ISBN: 9780132490207. (A free online textbook.) ↗
    Listed reading
  • Probstein: Probstein, R. F. Physiochemical Hydrodynamics: An Introduction . New York, NY: Wiley-Interscience, 2003. ISBN: 9780471458302.
    Listed reading
  • Jones: Jones, T. B. Electromechanics of Particles . 2nd ed. New York, NY: Cambridge University Press, 2005. ISBN: 9780521019101.
    Listed reading
  • Deen, W. “Stream Function.” Section 5.9 in Analysis of Transport Phenomena. New York, NY: Oxford University Press, 1998. ISBN: 9780195084948.
    Listed reading
  • Dill and Bromberg: Chapter 23
    Listed reading
  • LEC #: 26 · TOPICS: Transport 6 · DETAILS: Electrical analogy to understanding cell surface binding · READINGS: TY & K: 6.9
    Reading assignment
  • Quake, Stephen R., and Todd M. Squires. “Microfluidics: Fluid Physics at the Nanoliter Scale.” Reviews Of Modern Physics 77 (July 2005): 977-1026.
    Listed reading
  • Purcell, E. M. “Life at Low Reynolds Number.” American Journal of Physics 45, no. 1 (January 1977): 3-11.
    Listed reading
  • Deen, W. “Appendix A, Tables A-1 through A-4 (Vector Identity summary).” In Analysis of Transport Phenomena . New York, NY: Oxford University Press, 1998. ISBN: 9780195084948.
    Listed reading
  • Berg, H. C. “One-dimensional Random Walks.” In Random Walks in Biology . 2nd ed. Princeton, NJ: Princeton University Press, 1993. ISBN: 9780691000640.
    Listed reading
  • Halford, Stephen E., and John F. Marko. “How do Site-specifc DNA-binding Proteins Find their Targets?” Nucleic Acids Research 32, no. 10 (2004): 3040-3052.
    Listed reading
  • Brousseau, Louis C. “Label-Free ‘Digital Detection’ of Single-Molecule DNA Hybridization with a Single Electron Transistor.” J AM CHEM SOC 128 (2006): 11346-11347.
    Listed reading
  • Truskey, G. A., F. Yuan, and D. F. Katz. Transport Phenomena in Biological Systems . East Rutherford, NJ: Prentice Hall, 2003. ISBN: 9780130422040.
    Required
  • Haus, H. A., and J. R. Melcher. Electromagnetic Fields and Energy . Upper Saddle River, NJ: Prentice Hall, 1989. ISBN: 9780132490207. (A free online textbook.) ↗
    Required
  • Probstein, R. F. Physicochemical Hydrodynamics: An Introduction . New York, NY: Wiley-Interscience, 2003. ISBN: 9780471458302.
    Required
  • Jones, T. B. Electromechanics of Particles . 2nd ed. New York, NY: Cambridge University Press, 2005. ISBN: 9780521019101.
    Required
  • Bird, R. B., E. N. Lightfoot, and W. E. Stewart. Transport Phenomena . New York, NY: Wiley, 2006. ISBN: 9780470115398.
    Listed reading
  • Buy at MIT Press Weiss, T. F. Cellular Biophysics - Volume 1: Transport . Cambridge, MA: MIT Press, 1996. ISBN: 9780262231831. ↗
    Listed reading
  • Morgan, H., and H. Green. AC Electrokinetics: Colloids and Nanoparticles . Baldock, UK: Research Studies Press, 2002. ISBN: 9780863802553.
    Listed reading
  • Hiemenz, P. C., and R. Rajagopalan. Principles of Colloid and Surface Chemistry . New York, NY: Marcel Dekker, 1997. ISBN: 9780824793975.
    Listed reading
  • Dill, K., and S. Bromberg. Molecular Driving Forces . New York: Garland Press, 2002. ISBN: 9780815320517.
    Listed reading
Sources