6.881
Computational Personal Genomics: Making Sense of Complete Genomes
Spring 2016
With the growing availability and lowering costs of genotyping and personal genome sequencing, the focus has shifted from the ability to obtain the sequence to the ability to make sense of the resulting information. This course is aimed at exploring the computational challenges associated with interpreting how sequence differences between individuals lead to phenotypic differences in gene expression, disease predisposition, or response to treatment.
Readings
- Hartl, Daniel, and Andrew G. Clark. Principles of Population Genetics . Sinauer Associates, Incorporation, 2006. ISBN: 9780878933082. (3 copies in the MIT library)
Spring 2005 · Representation and Modeling for Image Analysis
Topics
- Introduction, Tutorial on PCA
- Eigenfaces
- Active Appearance Models
- Tutorial on EM
- Learning Flexible Sprites in Video Layers
- LLE and other Manifold Learning Methods
- EM Segmentation
- Tutorial on Calculus of Variations
- Mumford-Shah
- Snakes
- Geodesic Active Contours
- Shape Based Curve Evolution
- Tutorial on Clustering
- Spectral Clustering
- Normalized Cuts
- Graph Cuts for Energy Minimization
- Belief Propagation
- SIFT
- Constellation Model
- Shape Context
- Local Descriptors
- Object Recognition
- Finite Element Models
- Non-rigid Registration using B-splines
- Belief Propagation in Image Analysis
- Doing Photogrammetry Right
Readings
- LEC #: 9 · TOPICS: Mumford-Shah · Assigned Readings: Mumford, D., and J. Shah. “Boundary Detection by Minimizing Functionals, i.” In Proc. IEEE Conf. on Computer Vision & Pattern Recognition, San Francisco, CA, 1985.
- LEC #: 10 · TOPICS: Snakes · Assigned Readings: Kass, Michael, Andrew Witkin, and Demetri Terzopoulos. “Snakes: Active Contour Models.” Int. J. of Computer Vision 1, no. 4 (1987).
- LEC #: 12 · TOPICS: Shape Based Curve Evolution · Assigned Readings: Shape Based Curve Evolution 1
Sources
- Course catalogue ↗Historical OpenCourseWare
- MIT OCW readings ↗
- MIT OCW syllabus ↗
- MIT OpenCourseWare ↗Spring 2005
- MIT OCW syllabus ↗
- MIT OCW calendar ↗
- MIT OCW readings ↗
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.