Topics in Computational and Systems Biology
Seminar based on research literature. Papers covered are selected to illustrate important problems and varied approaches in the field of computational and systems biology, and to provide students a framework from which to evaluate new developments. Preference to first-year CSB PhD students.
Fall 2010
This is a seminar based on research literature. Papers covered are selected to illustrate important problems and approaches in the field of computational and systems biology, and provide students a framework from which to evaluate new developments. The MIT Initiative in Computational and Systems Biology ({{% resource_link "2348453e-d4c8-4530-ab42-438ec0082b73" "CSBi" %}}) is a campus-wide research and education program that links biology, engineering, and computer science in a multidisciplinary approach to the systematic analysis and modeling of complex biological phenomena. This course is one of a series of core subjects offered through the CSB Ph.D. program, for students with an interest in interdisciplinary training and research in the area of computational and systems biology.
Readings
- Benjamini, Eli, Richard Coico, and Geoffrey Sunshine. Chapters 1, 7, and 17 in Immunology: A Short Course . 5th ed. Hoboken, NJ: Wiley, 2003. ISBN: 9780471226895.
- (The first chapter gives a basic overview of immunology; chapter 7, p. 91 talks about B lymphocytes; and chapter 17, pp. 249-255, talks about lymphomas.)
- Zvelebil, Marketa, and Jeremy O. Baum. Understanding Bioinformatics . New York, NY: Garland Science, 2007. ISBN: 9780815340249. (Note: this text is highly recommended for 7.91 also)
- Alon, Uri. An Introduction to Systems Biology: Design Principles of Biological Circuits . Boca Raton, FL: Chapman & Hall, 2006. ISBN: 9781584886426. (A newer book that’s worth a look — systems biology from a physicist’s perspective.)
- Watson, J. D., T. A. Baker, S. P. Bell, A. Gann, M. Levine, and R. Losick. Molecular Biology of the Gene . 6th ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2007. ISBN: 9780805395921. (An updated version of the classic text.)
- Alberts, B., A. Johnson, J. Lewis, M. Raff, K. Roberts, and P. Walter. Molecular Biology of the Cell . 5th ed. New York, NY: Garland Science, 2008. ISBN: 9780815341055. (Another classic text.)
- Berg, J. M., J. L. Tymoczko, and L. Stryer. Biochemistry . 6th ed. New York, NY: W.H. Freeman, 2007. ISBN: 9780716787242. (Yet another classic.)
- Branden, C., and J. Tooze. Introduction to Protein Structure . 2nd ed. New York, NY: Garland Pub., 1999. ISBN: 9780815323051. (A gentle but authoritative introduction to the topic.)
Prerequisites & course information
Same subject as 7.89[J] Prereq: Permission of instructor G (Fall) 2-0-10 units
Sources
- Course catalogue ↗2026–2027
- MIT OpenCourseWare ↗Fall 2010
- MIT OCW readings ↗
- MIT OCW syllabus ↗
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.