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HST.035

Principle and Practice of Human Pathology

Graduate · Historical course

Spring 2003

Topics

  • Introduction to Human Pathology and Diagnostic Medicine (1 hr.) - Dr. Badizadegan
  • Cytoskeleton and the Extracellular Matrix: “Scaffoldings of Life” (1 hr.) - Dr. Ingber
  • Cell Injury, Adaptation and Death (1 hr.) - Dr. Badizadegan
  • Acute and Chronic Inflammation (1 hr.) - Dr. Badizadegan
  • Infectious Diseases: “The Biological Conflict of Interest” (1 hr.) - Dr. Badizadegan
  • Transplantation: “Friendly Organs in a Hostile Environment” (1 hr.) - Dr. Colvin
  • Host Response to Artificial Materials and Implanted Devices (1 hr.) - Dr. Schoen
  • Introduction to Organ Systems Pathology (1 hr.) - Dr. Badizadegan
  • Cardiomyopathies: “Many Roads to a Broken Heart” (1 hr.) - Dr. Seidman
  • Vascular Pathobiology: “Endothelium as Nature’s Blood Container” (1.5 hrs.) - Dr. Gimbrone
  • Patterns and Consequences of Glomerular Damage (1 hr.) - Dr. Rennke
  • Genetic Disorders (1 hr.) - Dr. Badizadegan
  • The Liver (1 hr.) - Dr. Badizadegan
  • Gastrointestinal Disorders: “Guts with No Glory!” (2 hrs.) - Dr. Badizadegan
  • Cervical Neoplasia: “Lessons from Viral Oncogenesis” (1 hr.) - Dr. Crum
  • Sickle Cell Disease: “From Membrane Pathophysiology to Membrane-Targeted Therapy” (1 hr.) - Dr. Brugnara
  • Introduction to the Nervous System (1 hr.)
  • Diseases of Skeletal Muscle (1 hr.) - Dr. Lidov
  • Surgical Pathology and Other Gold Standards (1 hr.) - Dr. Badizadegan
  • Bioinformatics in Pathology: “Can any Useful Information be Extracted from all this Data?” (1 hr.)
  • Lab: The Clinical Laboratories (Medical Area) (3 hrs.)
  • Optical Coherence Tomography: “Shedding Light on Human Disease” (1 hr.) - Dr. Tearney
  • Student Presentations (3 hrs.)
  • Autopsy: “The Final Answer?” (Medical Area) (1 hr.) - Dr. Badizadegan
  • Pathology and the Law (1 hr.) - Dr. Bieber

Readings

  • Cotran, et al. “Tumors of Colon and Rectum.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 827-835. ISBN: 9780721673356 .
    Listed reading
  • Houlston, R. S. “What We Could do Now: Molecular Pathology of Colorectal Cancer.” Mol Pathol 54, no. 4 (Aug 2001): 206-14.
    Listed reading
  • Peltomaki, P. “Role of DNA Mismatch Repair Defects in the Pathogenesis of Human Cancer.” J Clin Oncol 21, no. 6 (Mar 15, 2003): 1174-9.
    Listed reading
  • Cotran, et al. “Cervical Intraepithelial Neoplasia and Cancer.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1049-1053. ISBN: 9780721673356 .
    Listed reading
  • *zur Hausen, H. “Papillomaviruses and Cancer: From Basic Studies to Clinical Application.” Nat Rev Cancer 2, no. 5 (May 2002): 342-50.
    Listed reading
  • Cotran, et al. “Lymphoid Neoplasms.” Robbins Pathologic Basis of Disease . 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 651-658. ISBN: 9780721673356 . (all)
    Listed reading
  • ———. “AML.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 675-678. ISBN: 9780721673356 .
    Listed reading
  • *Shaffer, A. L., A. Rosenwald, and L. M. Staudt. “Lymphoid Malignancies: The Dark Side of B-cell Differentiation.” Nat Rev Immunol 2, no. 12 (Dec 2002): 920-32.
    Listed reading
  • Cotran, et al. “Sickle Cell Disease.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 611-615. ISBN: 9780721673356.
    Listed reading
  • Steinberg, M. H., and C. Brugnara. “Pathophysiological-based Approaches to Treatment of Sickle Cell Disease.” Annu Rev Med 54 (2003): 89-112. (Epub Dec 03, 2001).
    Listed reading
  • Cotran, et al. “Alzheimer Disease.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1329-1333. ISBN: 9780721673356.
    Listed reading
  • ———. “Parkinsonism.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1333-1334. ISBN: 9780721673356 .
    Listed reading
  • Taylor, J. P., J. Hardy, and K. H. Fischbeck. “Toxic Proteins in Neurodegenerative Disease.” Science 296, no. 5575 (Jun 14, 2002): 1991-5.
    Listed reading
  • Cotran, et al. “CNS Tumors.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1343-1348. ISBN: 9780721673356 .
    Listed reading
  • Louis, D. N., S. L. Pomeroy, and J. G. Cairncross. “Focus on Central Nervous System Neoplasia.” Cancer Cell 1, no. 2 (Mar 2002): 125-8.
    Listed reading
  • Louis, D. N., E. C. Holland, and J. G. Cairncross. “Glioma Classification: A Molecular Reappraisal.” Am J Pathol 159, no. 3 (Sep 2001): 779-86.
    Listed reading
  • Cotran, et al. “General Introduction.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1272-1275. ISBN: 9780721673356 .
    Listed reading
  • ———. “Diseases of Skeletal Muscle.” Robbins Pathologic Basis of Disease. 6th ed. Philadelphia, PA: W. B. Saunders, 1999, pp. 1280-1289. ISBN: 9780721673356 .
    Listed reading
  • *Carey, L., and L. Mitnik. “Trends in DNA Forensic Analysis.” Electrophoresis 23, no. 10 (May 2002): 1386-97.
    Listed reading
  • *Wang, N. “Methodologies in Cancer Cytogenetics and Molecular Cytogenetics.” Am J Med Genet 115, no. 3 (Oct 30, 2002): 118-24.
    Listed reading
  • Ramaswamy, S., and T. R. Golub. “DNA Microarrays in Clinical Oncology.” J Clin Oncol 20, no. 7 (Apr 2002): 1932-41.
    Listed reading
  • Weissleder, R., and U. Mahmood. “Molecular Imaging.” Radiology 219 (2001): 316-333.
    Listed reading
  • Weissleder, R. “Scaling Down Imaging: Molecular Mapping of Cancer in Mice.” Nat Rev Cancer 2, no. 1 (Jan 2002): 11-8.
    Listed reading
  • Burton, E. C. “The Autopsy: A Professional Responsibility in Assuring Quality of Care.” Am J Med Qual 17, no. 2 (Mar-Apr 2002): 56-60.
    Listed reading
  • Required reading for lectures related to cellular and organ system pathology are assigned from Cotran et al., Robbins Pathologic Basis of Disease, 6th edition. Philadelphia, PA: W. B. Saunders, 1999, ISBN: 9780721673356. Although not all sections and chapters of this book will be assigned for reading, students are highly encouraged to read this book cover-to-cover during the spring semester.
    Required
  • An Interactive Case Study Companion to Robbins Pathologic Basis of Disease is available online to registered HST students. This is a great resource for learning more and testing your knowledge about basic human pathology.
    Listed reading
  • Junqueira, L. C., and J. Carneiro. Basic Histology: Text and Atlas. 10th ed. New York, NY: McGraw-Hill Companies, 2002. ISBN: 9780071378291, is recommended for those interested in learning more about normal histology.
    Listed reading
  • Lodish H., et al. Molecular Cell Biology. 4th ed. New York, NY: McGraw-Hill, 1999. ISBN: 9780716731368, is recommended for those interested in learning more about cellular biology. A limited online version of this book is available through the National Library of Medicine.
    Listed reading
  • For additional reading in immunology and immunopathology, you can review Abbas, A. K. et al. Cellular and Molecular Immunology. Philadelphia, PA: W. B. Saunders, 2000. ISBN: 9780721682334.
    Listed reading
Sources