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HST.071

Human Reproductive Biology

4-0-2 units · Graduate

Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive science. Suggestions for future research contributions in the field are probed. Students become involved in the wider aspects of reproduction, such as prenatal diagnosis, in vitro fertilization, abortion, menopause, contraception and ethics relation to reproductive science. Only HST students may register under HST.070, graded P/D/F.

Fall 2005

Topics

  • Introduction to the Course (15 min.) - Dr. Henry Klapholz
  • Impotence (1 hr.) - Dr. Abe Morgentaler
  • Female System Anatomy (1 hr.) - Dr. Henry Klapholz
  • The Normal Menstrual Cycle (1 hr.) - Dr. Alan Penzias
  • Uterine Pathology: Fibroids (1 hr.) - Dr. Henry Klapholz
  • Non-hormonal Contraception I (1 hr.) - Dr. Henry Klapholz
  • Hormonal Contraception (1 hr.) - Dr. Henry Klapholz
  • The Placenta (1 hr.) - Dr. Drucilla Roberts
  • The Cervix (1 hr.) - Dr. Henry Klapholz
  • Sexual Differentiation I (1 hr.) - Dr. Patricia Donahoe
  • Infertility (1 hr.) - Dr. Selwyn Oskowitz
  • Maternal Physiology I (1 hr.) - Dr. Henry Klapholz
  • Hypertension in Pregnancy (1 hr.) - Dr. Kee-Hak Lim
  • Uterine Physiology (1 hr.) - Dr. Henry Klapholz
  • Polycystic Ovarian Syndrome (PCO) (1 hr. 15 min.) - _Dr. Robert Barbieri
  • Toxoplasmosis (1 hr.) - Dr. Henry Klapholz
  • Teratology (1 hr. 25 min.) - Dr. Lewis Holmes
  • Energy and Radiation Impact on Pregnancy (1 hr.) - Dr. Henry Klapholz
  • Fetal Surveillance (1 hr.) - Dr. Henry Klapholz
  • Film Viewing: The Way It Was (1 hr.)

Readings

  • vanNagell, J. R., and P. D. DePriest. “Management of Adnexal Masses in Postmenopausal Women.” Am J Obs Gyn 193 (2005): 30-35.
    Listed reading
  • Tiffen, J., and S. M. Mahon. “Ovarian Cancer Screening: Are There Any Options?” Clin J Onc Nurs 9 (2005): 369-372.
    Listed reading
  • Berkley, K. J., A. J. Rapkin, and R. E. Papke. “The Pains of Endometriosis.” Science 308 (2005): 1587-89.
    Listed reading
  • Giudice, L. C., and L. C. Kao. “Endometriosis.” Lancet 364 (2004): 1789-99.
    Listed reading
  • Armour, K. “Using Surveillance to Improve Maternal and Fetal Outcomes.” AWHONN Lifelines 8: 232-240.
    Listed reading
  • Supplement Article: J AIDS 38 (2005): S1-S23.
    Listed reading
  • Kaunitz, A. M. “Beyond the Pill: New Data and Options in Hormonal and Intrauterine Contraception.” Am J Obs Gyn 192 (2005): 998-1004.
    Listed reading
  • Hoffman, S., J. Mantell, T. Exner, and Z. Stein. “The Future of the Female Condom.” Pers Sex Reprod Health 36 (2004): 120-125.
    Listed reading
  • Nie, G., A. R. Butt, L. A. Salamonsen, and J. K. Findlay. “Hormonal and Non-Hormonal Agents at Implantation as Targets for Contraception.” Reprod Fertil Dev 9 (1997): 65-76.
    Listed reading
  • Beck, V., U. Rohr, and A. Jungbauer. “Phytoestrogen Derived from Red Clover: An Alternative to Estrogen Replacement Therapy?” J Ster Bioch Mol Bio 94 (2005): 499-518.
    Listed reading
  • National Institutes of Health. “State-of-the-Science Conference Statement: Management of Menopause-Related Symptoms.” Ann Int Med 142 (2005): 1003-1013.
    Listed reading
  • Emperaire, J. C., and R. G. Edwards. “Time to Revolutionize the Triggering of Ovulation.” Reprod BioMed 5 (2004): 480-483.
    Listed reading
  • Wilkinson, D., M. Tholandi, G. Ramjee, and G. W. Rutherford. “Nonoynol-9 Spermicide for Prevention of Vaginally Acquired HIV and Other Sexually Transmitted Infections: Systematic Review and Meta-Analysis of Randomized Controlled Trials Including more than 5000 Women.” Lancet 2 (2002): 613-617.
    Listed reading
  • Karumanchi, S. A., S. E. Maynard, I. E. Stillman, F. H. Epstein, and V. P. Sukhatme. “Preeclampsia: A Renal Perspective.” Kid Int 67 (2005): 2101-2113.
    Listed reading
  • Lapinsky, S. E. “Cardiopulmonary Complications of Pregnancy.” Crit Care Med 33 (2005): 1616-1622.
    Listed reading
  • Ross, L. E., B. J. Murray, and M. Steiner. “Sleep and Perinatal Mood Disorders: A Critical Review.” J Psych Neurosci 30 (2005): 247-256.
    Listed reading
  • Lambert-Messerlian, G. M., H. Pinar, E. Laprade, U. Tantravahi, A. Schneyer, and J. A. Canick. “Inhibins and Activins in Human Fetal Abnormalities.” Molec and Cell End 255 (2004): 101-108.
    Listed reading
  • Kuliev, A., and Y. Verlinsky. “Place of Preimplantation Diagnosis in Genetic Practice.” Am J Med Gen 134A (2005): 105-110.
    Listed reading
  • Havelock, J. C., R. J. Auchus, and W. E. Rainey. “The Rise in Adrenal Androgen Biosynthesis: Adrenarche.” Sem Repr Med 22 (2004): 337-347.
    Listed reading
  • Waylen, A., and D. Wolke. “Sex ’n’ Drugs ’n’ Rock ’n’ Roll: The Meaning and Social Consequences of Pubertal Timing.” Eur J End 151 (2004): 151-159.
    Listed reading
  • Thaplial, A., U. Ramachandran, K. K. Sharma, P. Gautam, and N. Sarkar. “Rh Iso-Immunisation with Syndrome of Hepatocellular Damage. An Unusual Presentation with Review of Literature.” Int J Clin Pract 58, no. 11 (November 2004): 1056-60.
    Listed reading
  • MacLaughlin, D. T., and P. K. Donahoe. “Sex Determination and Differentiation.” N Eng J Med 350 (2004): 367-378.
    Listed reading
  • De Santis, M., E. D. Gianantonio, G. Straface, A. F. Cavaliere, A. Caruso, F. Schiavon, R. Berletti, and M. Clementi. “Ionizing Radiations in Pregnancy and Teratogenesis: A Review of Literature.” Reprod Tox 20 (2005): 323-329.
    Listed reading
  • Zindler, L. “Ethical Decision Making in First Trimester Pregnancy.” J Perinat Neonat Nurs 19 (2005): 122-131.
    Listed reading
  • Say, L., R. Kulier, M. Gulmezoglu, and A. Campana. “Medical versus Surgical Methods for First Trimester Termination of Pregnancy.” Cochrane Database Syst Rev 1 (January 25, 2005): CD003037.
    Listed reading
  • Seki, K., H. Matsui, and S. Sekiya. “Advances in the Clinical Laboratory Detection of Gestational Trophoblastic Disease.” Clinica Chimica Acta 349 (2004): 1-13.
    Listed reading
  • Devriendt, K. “Hyatidiform Mole and Triplody: The Role of Genomic Imprinting in Placental Development.” Hum Reprod Up 11 (2005): 137-142.
    Listed reading
  • Soper, J. T., D. G. Mutch, and J. C. Schink. “Diagnosis and Treatment of Gestational Trophoblastic Disease: ACOG Practice Bulletin No. 53.” Gyn Onc 93 (2004): 575-585.
    Listed reading
  • Kravetz, J. D., and D. G. Federman. “Toxoplasmosis in Pregnancy.” Am J Med 118 (2005): 212-216.
    Listed reading
  • Bulletti, C., D. De Ziegler, P. L. Setti, E. Cicinelli, V. Polli, and C. Flamigni. “The Patterns of Uterine Contractility in Normal Menstruating Women: From Physiology to Pathology.” Ann NY Acad Sci 1034 (2004): 64-83.
    Listed reading
  • Surani, M. A. “Stem Cells: How to Make Eggs and Sperm.” Nature 427, no. 6970 (January 8, 2004): 106-7.
    Listed reading
  • Geijsen, N., M. Horoschak, K. Kim, J. Gribnau, K. Eggan, and G. Q. Daley. “Derivation of Embryonic Germ Cells and Male Gametes from Embryonic Stem Cells.” Nature 427, no. 6970 (January 8, 2004): 148-54. Epub 2003 December 10.
    Listed reading
  • Saitou, M., S. C. Barton, and M. A. Surani. “A Molecular Programme for the Specification of Germ Cell Fate in Mice.” Nature . 148, no. 6895 (July 18, 2002): 293-300.
    Listed reading
  • Blackwell, T. K. “Germ Cells: Finding Programs of Mass Repression.” Curr Biol 14, no. 6 (March 23, 2004): R229-30.
    Listed reading
  • Johnson, J., J. Bagley, M. Skaznik-Wikiel, H. J. Lee, G. B. Adams, Y. Niikura, K. S. Tschudy, J. C. Tilly, M. L. Cortes, R. Forkert, T. Spitzer, J. Iacomini, D. T. Scadden, and J. L. Tilly. “Oocyte Generation in Adult Mammalian Ovaries by Putative Germ Cells in Bone Marrow and Peripheral Blood.” Cell 122, no. 2 (July 29, 2005): 303-15.
    Listed reading
  • Hubner, K., G. Fuhrmann, L. K. Christenson, J. Kehler, R. Reinbold, R. De La Fuente, J. Wood, J. F. Strauss 3rd, M. Boiani, and H. R. Scholer. “Derivation of Oocytes from Mouse Embryonic Stem Cells.” Science 300, no. 5623 (May 23, 2003): 1251-6. (Epub May 1, 2003)
    Listed reading
  • McLaren, A. “Primordial Germ Cells in the Mouse.” Dev Biol 262, no. 1 (October 1, 2003): 1-15.
    Listed reading
  • Cantor, J., and K. Baum. “The Limits of Conscientious Objection–may Pharmacists Refuse to Fill Prescriptions for Emergency Contraception?” N Engl J Med 351, no. 19 (November 4, 2004): 2008-12.
    Listed reading

Prerequisites & course information

Subject meets with HST.070 Prereq: 7.05 and permission of instructor G (Fall; first half of term) 4-0-2 units

Sources