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HST.131

Neuroscience

6-2-6 units · Graduate

Comprehensive study of neuroscience where students explore the brain on levels ranging from molecules and cells through neural systems, perception, memory, and behavior. Includes some aspects of clinical neuroscience, within neuropharmacology, pathophysiology, and neurology. Lectures supplemented by conferences and labs. Labs review neuroanatomy at the gross and microscopic levels. Only HST students may register under HST.130 , graded P/D/F. Limited to 50.

Fall 2005 · Introduction to Neuroscience

Topics

  • Ion Channels Permeation - Prof. David P. Corey
  • Ion Channel Gating - Prof. David Corey
  • Action Potentials and Axonal Conduction - Prof. David P. Corey
  • Synaptic Overview and Neuromuscular Junct - Prof. Thomas L. Schwarz
  • Mechanisms of Transmitter Release - Prof. Thomas L. Schwarz
  • Ion Channel Disease - Prof. Robert H. Brown
  • G-Protein Linked Receptors - Prof. Thomas L. Schwarz
  • Synaptic Integration - Prof. Rachel Wilson
  • Epilepsy - Prof. Elizabeth Anne Thiele
  • Overview, Meninges - Prof. Matthew P. Frosch
  • Peripheral Nerves and Cranial Nerves - Prof. Matthew P. Frosch
  • Cranial Nerve Nuclei - Prof. Matthew P. Frosch
  • Brainstem Tracts and Review - Prof. Matthew P. Frosch
  • Cerebellum - Prof. Matthew P. Frosch
  • Thalamus and Hypothalamus - Prof. Matthew P. Frosch
  • Basal Ganglia - Prof. Matthew P. Frosch
  • Cerebral Cortex - Prof. Matthew P. Frosch
  • New Approaches to Brain Imaging - Prof. Bruce Robert Rosen
  • Limbic System II and Diffuse Projecting System - Prof. Matthew P. Frosch
  • Vasculature - Prof. Matthew P. Frosch
  • Light Detection by Retina - Prof. Richard H. Masland
  • Primary Visual Coding - Prof. Richard H. Masland
  • Visual Processing in the Cortex - John A. Assad
  • Somatic Sensation - Prof. David P. Corey
  • Hair Cells of the Inner Ear - Prof. David P. Corey
  • Vestibular System/VOR - Prof. David P. Corey
  • Motor II: Brainstem and Cortex - John A. Assad
  • Motor IV: Basal Ganglia - Prof. Emad Eskandar
  • Parkinson Disease - Prof. Martin A. Samuels
  • Neural Cell Fates - Lisa V. Goodrich
  • Axon Guidance and Myelination - Lisa V. Goodrich
  • Synapse Formation: Presynaptic - Prof. Joshua Sanes
  • Activity-Dependent Development - Prof. Carla J. Shatz
  • Spinal Cord Injury - Prof. Zhigang He
  • Excitotoxicity and Stroke - Prof. Frances E. Jensen
  • Memory - Prof. Andrew E. Budson
  • Fear - Prof. Steven E. Hyman

Readings

  • Kandel, Eric R., James H. Schwartz, and Thomas M. Jessell. Principles of Neural Science . 4th ed. New York, NY: McGraw-Hill, Health Professions Division, 2000. ISBN: 9780838577011 .
    Required
  • Becker, E. B., and A. Bonni. “Cell cycle regulation of neuronal apoptosis in development and disease.” Prog Neurobiol 72, no. 1 (January 2004): 1-25.
    Required
  • Emsley, J. G., B. D. Mitchell, G. Kempermann, and J. D. Macklis. “Adult neurogenesis and repair of the adult CNS with neural progenitors, precursors, and stem cells.” Prog Neurobiol 75, no. 5 (April 2005): 321-41.
    Required
  • Gage, F. H. “Mammalian neural stem cells.” Science 287, no. 5457 (February 25, 2000): 1433-8.
    Required
  • Hensch, T. K. “Critical period regulation.” Annu Rev Neurosci , no. 27 (2004): 549-79.
    Required
  • Hyman, S. E., and R. C. Malenka. “Addiction and the brain: the neurobiology of compulsion and its persistence.” Nat Rev Neurosci 2, no. 10 (October 2001): 695-703.
    Required
  • LeDoux, J. “The emotional brain, fear, and the amygdala.” Cell Mol Neurobiol 23, no. 4-5 _(_October 2003): 727-38.
    Required
  • Lipton, S. A., and P. A. Rosenberg. “Excitatory amino acids as a final common pathway for neurologic disorders.” N Engl J Med 330, no. 9 (March 3, 1994): 613-22.
    Required
  • Maren, S. “Neurobiology of Pavlovian fear conditioning.” Annu Rev Neurosci , no. 24 (2001): 897-931.
    Required
  • Miller, R. H. “Regulation of oligodendrocyte development in the vertebrate CNS.” Prog Neurobiol 67, no. 6 (August 2002): 451-67.
    Required
  • Mooney, R. “Sensitive periods and circuits for learned birdsong.” Curr Opin Neurobiol 9, no. 1 (February 1999): 121-7.
    Required
  • Penn, A. A., and C. J. Shatz. “Brain waves and brain wiring: the role of endogenous and sensory-driven neural activity in development.” Pediatr Res. 45, no. 4 Pt 1 (April 1999): 447-58.
    Required
  • Schwab, M. E. “Repairing the injured spinal cord.” Science 295, no. 5557 (February 8, 2002): 1029-31.
    Required
  • Walsh, D. M., and D. J. Selkoe. “Deciphering the molecular basis of memory failure in Alzheimer’s disease.” Neuron 44, no. 1 (September 30, 2004): 181-93.
    Required
  • Arlotta, P., B. J. Molyneaux, J. Chen, J. Inoue, R. Kominami, and J. D. Macklis. “Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo.” Neuron 45, no. 2 (January 20, 2005): 207-21.
    Recommended
  • Basch, M. L., M. I. Garcia-Castro, and M. Bronner-Fraser. “Molecular mechanisms of neural crest induction.” Birth Defects Res C Embryo Today 72, no. 2 (June 2004): 109-23.
    Recommended
  • Botto, L. D., C. A. Moore, M. J. Khoury, and J. D. Erickson. “Neural-tube defects.” N Engl J Med 341, no. 20 (November 11, 1999): 1509-19.
    Recommended
  • Clark, G. D. “The classification of cortical dysplasias through molecular genetics.” Brain Dev 26, no. 6 (September 2004): 351-62.
    Recommended
  • Copp, A. J., N. D. Greene, and J. N. Murdoch. “The genetic basis of mammalian neurulation.” Nat Rev Genet 4, no. 10 (October 2003): 784-93.
    Recommended
  • Dent, E. W., and F. B. Gertler. “Cytoskeletal dynamics and transport in growth cone motility and axon guidance.” Neuron 40, no. 2 (October 9, 2003): 209-27.
    Recommended
  • Farlie, P. G., S. J. McKeown, and D. F. Newgreen. “The neural crest: basic biology and clinical relationships in the craniofacial and enteric nervous systems.” Birth Defects Res C Embryo Today 72, no. 2 (June 2004): 173-89.
    Recommended
  • Goda, Y., G. W. Davis. “Mechanisms of synapse assembly and disassembly.” Neuron 40, no. 2 (October 9, 2003): 243-64.
    Recommended
  • Grove, E. A., and T. Fukuchi-Shimogori. “Generating the cerebral cortical area map.” Annu Rev Neurosci , no. 26 (2003): 355-80.
    Recommended
  • Hyman, S. E. “Brain neurocircuitry of anxiety and fear: implications for clinical research and practice.” Biol Psychiatry 44, no. 12 (December 15, 1998): 1201-3.
    Recommended
  • Kiecker, C., A. Lumsden. “Compartments and their boundaries in vertebrate brain development.” Nat Rev Neurosci 6, no. 7 (July 2005): 553-64.
    Recommended
  • Koman, K. “The Science of Hurt: Medical researchers and doctors work to close the “gates” on pain.” Harv Mag 108, no. 2 (November 2005): 46-54.
    Recommended
  • Magavi, S. S., B. R. Leavitt, and J. D. Macklis. “Induction of neurogenesis in the neocortex of adult mice.” Nature 405, no. 6789 (June 22, 2000): 951-5.
    Recommended
  • Molyneaux, B. J., P. Arlotta, T. Hirata, M. Hibi, and J. D. Macklis. “Fezl is required for the birth and specification of corticospinal motor neurons.” Neuron 47, no. 6 (September 15, 2005): 817-31.
    Recommended
  • Mullor, J. L., P. Sanchez, and A. R. Altaba. “Pathways and consequences: Hedgehog signaling in human disease.” Trends Cell Biol 12, no. 12 (December 2002): 562-9.
    Recommended
  • Porter, B. E., and G. Tennekoon. “Myelin and disorders that affect the formation and maintenance of this sheath.” Ment Retard Dev Disabil Res Rev 6, no. 1 (2000): 47-58.
    Recommended
  • Schwarz, Thomas L. “Release of Neurotransmitters.” Chapter 8 in Fundamental Neuroscience , edited by Larry R. Squire, Floyd E. Bloom, Susan K. McConnell, James L. Roberts, Nicholas C. Spitzer, and Michael J. Zigmond. 2nd ed. San Diego, CA: Academic Press, 2002. ISBN: 9780126603033 .
    Recommended
  • Stern, C. D. “Neural induction: old problem, new findings, yet more questions.” Development 132, no. 9 (May 2005): 2007-21.
    Recommended
  • Yu, T. W., and C. I. Bargmann. “Dynamic regulation of axon guidance.” Nat Neurosci 4 (November 2001): 1169-76. (Supplementary)
    Recommended
  • Kandel, Eric R., James H. Schwartz, and Thomas M. Jessell, eds. Principles of Neural Science . 4th ed. New York, NY: McGraw-Hill, Health Professions Division, 2000. ISBN: 9780838577011.
    Listed reading

Prerequisites & course information

Subject meets with HST.130 Prereq: Permission of instructor G (Fall) 6-2-6 units

Sources