everything.study
HST.176

Cellular and Molecular Immunology

6-0-6 units · Graduate

Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of each case covering a number of immunological issues in the context of disease are posted on a student website. Only HST students may register under HST.175 , graded P/D/F. Limited to 45.

Fall 2005

Topics

  • Overview - Dr. Shiv Pillai
  • Cells of the Immune System - Dr. Shiv Pillai
  • Lymphocyte Homing - Dr. Ulrich von Andrian
  • Case Presentations at MGH
  • Antibodies and Antigens - Dr. Shiv Pillai
  • Antigen Receptors and the Generation of Diversity - Dr. Shiv Pillai
  • B Lymphocyte Development and Activation - Dr. Shiv Pillai
  • Tutorial Session I
  • Antigen Presentation - Dr. Hidde Ploegh
  • Tutorial Session II
  • Tutorial Session III
  • Cell Mediated Immunity - Dr. Andrew Lichtman
  • Tutorial Session IV
  • Paper Discussion 1
  • Dendritic Cells - Dr. Shannon Turley
  • Paper Discussion 2
  • Memory and Death - Dr. Shiv Pillai
  • Tutorial Session V
  • Asthma and Allergy - Dr. Dale T. Umetsu
  • Multiple Sclerosis - Dr. David Hafler
  • Paper Discussion 3
  • Leukemias and Lymphomas - Dr. Jon C. Aster
  • Tutorial Session VI
  • Immunology of HIV/AIDS - Dr. Bruce Walker
  • Regulatory T Cells - Dr. Diane Mathis
  • Tutorial Session VII
  • Paper Discussion 4
  • Regulating Humoral Autoimmunity - Dr. Shiv Pillai
  • Immunodeficiency Disorders - Dr. Francisco Bonilla
  • RA and Lupus - Dr. Paul Anderson
  • Genetic Susceptibility to Disease - Dr. Shiv Pillai

Readings

  • Abbas, Abul K., and Andrew Lichtman. Cellular and Molecular Immunology . 6th ed. Philadelphia, PA: Saunders, 2005. ISBN: 9781416023890.
    Required
  • Rosen, Fred, and Raif Geha. Case Studies in Immunology: A Clinical Companion . 4th ed. New York, NY: Garland Pub., 2004. ISBN: 9780815341024. (Paperback)
    Required
  • Janeway, Charles A., et al. Immunobiology: The Immune System in Health and Disease . New York, NY: Garland Science, 2004. ISBN: 9780443073106 .
    Required
  • DeGowin, Richard L., and Donald D. Brown. DeGowin’s Diagnostic Examination . New York, NY: McGraw-Hill, Health Professions Division, 1999. ISBN: 9780070164437.
    Required
  • Kasper, Dennis L., Eugene Braunwald, Anthony Fauci, Stephen Hauser, Dan Longo, and J. Larry Jameson. Harrison’s Principles of Internal Medicine . 16th ed. New York, NY: McGraw-Hill, Medical Pub. Division, 2004. ISBN: 9780071402354 .
    Required
  • SES #: 15 · TOPICS: Paper Discussion 1 · READINGS: Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. “CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs.” Cell 99, no. 1 (October 1, 1999): 23-33.
    Reading assignment
  • SES #: 17 · TOPICS: Paper Discussion 2 · READINGS: Fisher, G. H., F. J. Rosenberg, S. E. Straus, J. K. Dale, L. A. Middleton, A. Y. Lin, W. Strober, M. J. Lenardo, and J. M. Puck. “Dominant interfering Fas gene mutations impair apoptosis in a human autoimmune lymphoproliferative syndrome.” Cell 81, no. 6 (June 16, 1995): 935-46.
    Reading assignment
  • SES #: 22 · TOPICS: Paper Discussion 3 · READINGS: Murali-Krishna, K., L. L. Lau, S. Sambhara, F. Lemonnier, J. Altman, and R. Ahmed. “Persistence of memory CD8 T cells in MHC class I-deficient mice.” Science 286, no. 5443 (November 12, 1999): 1377-81.
    Reading assignment
  • SES #: 28 · TOPICS: Paper Discussion 4 · READINGS: Fontenot, J. D., M. A. Gavin, and A. Y. Rudensky. “Foxp3 programs the development and function of CD4+CD25+ regulatory T cells.” Nat Immunol 4, no. 4 (April 2003): 330-6. (Epub March 3, 2003)
    Reading assignment
  • McMichael, A. J., and S. L. Rowland-Jones. “HIV: Bad news for stop-start therapy?” Nature 420, no. 6914 (November 28, 2002): 371, and 373.
    Recommended
  • Chaudhuri, J., M. Tian, C. Khuong, K. Chua, E. Pinaud, F. W. Alt. “Transcription-targeted DNA deamination by the AID antibody diversification enzyme.” Nature 422, no. 6933 (April 17, 2003): 726-30. (Epub April 9, 2003)
    Recommended
  • Rosen, F. S., M. D. Cooper, and R. J. Wedgwood. “The primary immunodeficiencies.” N Engl J Med 333, no. 7 (August 17, 1995): 431-40.
    Recommended
  • A “basic” textbook and a clinical textbook are recommended. The recommended books are:
    Listed reading
  • Abbas, Abul K., and Andrew Lichtman. Cellular and Molecular Immunology . 6th ed. Philadelphia, PA: Saunders, 2005. ISBN: 9781416023890.
    Listed reading
  • Rosen, Fred, and Raif Geha. Case Studies in Immunology: A Clinical Companion . 4th ed. New York, NY: Garland Pub., 2004. ISBN: 9780815341024. (Paperback)
    Listed reading
  • Reading of textbook chapters before the class is strongly recommended. For many of the lectures the contents of the slides are summarized in the course camel. The current edition of the following book may also be used:
    Listed reading
  • Janeway, Charles A., et al. Immunobiology: The Immune System in Health and Disease . New York, NY: Garland Science, 2004. ISBN: 9780443073106.
    Listed reading

Prerequisites & course information

Subject meets with HST.175 Prereq: 7.05 G (Fall) 6-0-6 units

Sources