everything.study
HST.512

Genomic Medicine

Graduate · Historical course

Spring 2004

Topics

  • Genomic Introduction
  • Introduction to Biology and Genomic Measurement
  • Measurement Techniques - Butte
  • Microarray - Massively Parrallel Measuremment
  • Limits of Technologies
  • Information Science at the Center of Genomic Medicine
  • Informational Resources
  • Complex Traits: What to Believe
  • Machine-learning Approach
  • Association with Markers
  • The Importance of Data Representation
  • Pharmacogenomics
  • Case Hx: Complex Traits
  • Individualized Pharmacology
  • Microarray Disease Classification
  • Microarray Disease Classification II
  • Direct Prediction of Outcome / Mortality
  • Case Hx: Cancer Diagnostics
  • Modelling and Reverse Engineering
  • Practical Genomic Medicine

Readings

  • Bell, John I. “The Double Helix in Clinical Practice.” Nature 421 (23 January 2003): 414-416.
    Listed reading
  • Boffeli, Dario, et al. “Phylogenetic Shadowing of Primate Sequences to Find Functional Regions of the Human Genome.” Science 299 (28 February 2003): 1391-1394.
    Listed reading
  • Gilbertson, Richard J., and Steven C. Clifford. “PDGFRB Is Overexpressed in Metastatic Medulloblastoma.” Nature Genetics 35, no. 3 (November 2003): 197-198.
    Listed reading
  • Gollust, Sarah E., Sarah Chandros Hull, and Benjamin S. Wilfond. “Limitations of Direct-to-Consumer Advertisingg for Clinical Genetic Testing.” Journal of the American Medical Association 288, no. 14 (9 October 2002): 1762-1767.
    Listed reading
  • Green, Mark R. “Targeting Targeted Therapy” (editorial). New England Journal of Medicine 350, no. 21 (20 May 2004): 2191-2193.
    Listed reading
  • Guttmacher, Alan E., and Francis S. Collins. “Genomic Medicine - A Primer.” New England Journal of Medicine 347, no. 19 (7 November 2002): 1512-1520.
    Listed reading
  • Harmon, Amy. “As Gene Test Menu Grows, Who Gets to Choose?” New York Times 21 July 2004.
    Listed reading
  • Khoury, Muin J., Linda L. McCabe, and Edward R. McCabe. “Population Screening in the Age of Genomic Medicine.” New England Journal of Medicine 348, no. 16 (17 April 2003): 1604-1605.
    Listed reading
  • Korf, Bruce R. “Genetics in Medical Practice.” Genetics in Medicine 4, no. 6, supplement (November-December 2002): 10S-14S.
    Listed reading
  • Ledley, Fred. “A Consumer Charter for Genomic Services.” Nature Biotechnology 20 (August 2002): 767.
    Listed reading
  • Lohmueller, Kirk E., et al. “Meta-analysis of Genetic Association Studies Supports a Contribution of Common Variants to Susceptibility to Common Disease” (letter). Nature Genetics 33 (February 2003): 177-182.
    Listed reading
  • Lynch, Thomas J., et al. “Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non-Small-Cell Lung Cancer to Gefitinib.” New England Journal of Medicine 350, no. 21 (20 May 2004): 2129-2139.
    Listed reading
  • “The Personal Genome Sequencer.” Technology Review (November 2002): 76-79.
    Listed reading
  • Rusnak, James M., et al. “Pharmacogenomics: A Clinician’s Primer on Emerging Technologies for Improved Patient Care.” Mayo Clinic Proceedings 76 (2001): 299-309.
    Listed reading
  • Sharpe, James, et al. “Optical Projection Tomography as a Tool for 3D Microscopy and Gene Expression Studies.” Science 296 (19 April 2002): 541-545.
    Listed reading
  • Tefferi, Ayalew, et al. “Primer on Medical Genomics - Part II: Background Principles and Methods in Molecular Genetics.” Mayo Clinic Proceedings 77 (2002): 785-808.
    Listed reading
  • Tilstone, Clare. “DNA Microarrays: Vital Statistics.” Nature 424 (7 Aug 2003): 610-612.
    Listed reading
  • Varmus, Harold. “Getting Ready for Gene-Based Medicine” (editorial). New England Journal of Medicine 347, no. 19 (7 November 2002): 1526-1527.
    Listed reading
  • Wang, David, et al. “Microarray-based Detection and Genotyping of Viral Pathogens.” Proceedings of the National Academy of Sciences 99, no. 24 (26 November 2002): 15687-15692.
    Listed reading
  • “Informed Consent for Diagnostic Genetic Testing. Fact Form for Patients.” Société Suisse de Génétique Médicale, Berne, Switzerland, 26 November 2001.
    Listed reading
  • Brown, Terence A. Genomes. 2nd ed. Wiley-Liss, June 15, 2002. ISBN: 9780471250463 .
    Listed reading
  • Buy at MIT Press Kohane, Isaac S., Alvin Kho, and Atul J. Butte. Microarrays for an Integrative Genomics . MIT Press, August 21, 2002. ISBN: 9780471250463 . ↗
    Listed reading
  • Dhanda, Rahul K. Guiding Icarus: Merging Bioethics with Corporate Interests. 1st ed. Wiley-Liss, April 5, 2002. ISBN: 9780471223801 .
    Listed reading
Sources