Biomaterials: Tissue Interactions
Principles of materials science and cell biology underlying the development and implementation of biomaterials for the fabrication of medical devices/implants, including artificial organs and matrices for tissue engineering and regenerative medicine. Employs a conceptual model, the "unit cell process for analysis of the mechanisms underlying wound healing and tissue remodeling following implantation of biomaterials/devices in various organs, including matrix synthesis, degradation, and contraction. Methodology of tissue and organ regeneration. Discusses methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.
Fall 2022 · Biomaterials-Tissue Interactions
The goal of this course is to teach the principles of materials science, chemical and mechanical engineering, and cell biology underlying the use of materials for the development of implantable and injectable devices.
Fall 2009 · Biomaterials-Tissue Interactions
This course covers the principles of materials science and cell biology underlying the design of medical implants, artificial organs, and matrices for tissue engineering. Methods for biomaterials surface characterization and analysis of protein adsorption on biomaterials. Molecular and cellular interactions with biomaterials are analyzed in terms of unit cell processes, such as matrix synthesis, degradation, and contraction. Mechanisms underlying wound healing and tissue remodeling following implantation in various organs. Tissue and organ regeneration. Design of implants and prostheses based on control of biomaterials-tissue interactions. Comparative analysis of intact, biodegradable, and bioreplaceable implants by reference to case studies. Criteria for restoration of physiological function for tissues and organs.
Readings
- This page lists the readings assigned per class session. Chapters from the course textbook are cited as:
- [TORA] = Yannas, I. V. Tissue and Organ Regeneration in Adults . New York, NY: Springer, 2001. ISBN: 9780387952147.
- Gehrig, L., and M. I. O’Connor. “Putting Sex in Your Orthopaedic Practice.” AAOS Now , June 2008.
- Darnell, J. E., H. F. Lodish, and D. Baltimore. “Laminin, Fibronectin and Other Multiadhesive Matrix Glycoproteins.” Chapter 23.4 in Molecular Cell Biology . 2nd ed. New York, NY: W. H. Freeman, 1990, pp. 920-924. ISBN: 9780716719816.
- LEC #: 6 · TOPICS: ECM does not regenerate spontaneously · READINGS: [TORA], Chapters 1 and 2
- Andrade, J. D., ed. Excerpts from “Principles of Protein Adsorption.” Chapter 1 in Surface and Interfacial Aspects of Biomedical Polymers, Vol. 2. Protein Adsorption . New York, NY: Plenum Press, 1985. ISBN: 9780306417412.
- [TORA], Chapters 9 and 10
- LEC #: 18 · TOPICS: In vivo synthesis of skin · READINGS: [TORA], Chapter 5
- [TORA], Chapter 6
- LEC #: 20 · TOPICS: Rules for synthesis of tissues and organs · READINGS: [TORA], Chapter 7
- Readings from the literature will be assigned for many classes. Selected readings will also be assigned from the course textbook:
- Yannas, I. V. Tissue and Organ Regeneration in Adults . New York, NY: Springer, 2001. ISBN: 9780387952147.
Prerequisites & course information
Same subject as 2.79[J] Prereq: ( Biology (GIR) , Chemistry (GIR) , and Physics I (GIR) ) or permission of instructor G (Fall) Not offered regularly; consult department 3-0-9 units
Sources
- Course catalogue ↗2026–2027
- MIT OpenCourseWare ↗Fall 2022
- MIT OCW calendar ↗
- MIT OCW syllabus ↗
- MIT OpenCourseWare ↗Fall 2009
- MIT OCW readings ↗
- MIT OCW syllabus ↗
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.