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HST.560

Radiation Biophysics

3-0-9 units · Graduate

See description under subject 22.55[J] .

Fall 2004 · Principles of Radiation Interactions

Topics

  • Course Intro/Cells and Tissues Overview
  • Radiation Interactions
  • Radiation Interactions (cont.)
  • Radiation Chemistry/LET/Tracks
  • Effects on Chromosomes/DNA
  • Dose Response in Vitro: Cell Survival Curves
  • RBE/Clustered Damage
  • Protons and Alphas of same LET
  • Dose Response in Vivo
  • Chemical Modification of Radiation Response
  • Cell, Tissue and Tumor Kinetics
  • Radiation Therapy: Tumor Radiobiology
  • Radiation Therapy (contd.): Fractionation
  • Acute Effects of Whole Body Exposure
  • Late Effects: Chronic Exposure/Low Doses
  • Radiation Protection/Background Radiation/Radon
  • Alpha Particles/Bystander Effect
  • Microbeams
  • RBE of Diagnostic X Rays
  • BNCT/Other Modalities
  • Space
  • Space (cont.)
  • Oral Term Paper Presentations

Readings

  • Rydberg, Björn, William R. Holley, I. Saira Mian, and Aloke Chatterjee. “Chromatin Conformation in Living Cells: Support for a Zig-Zag Model of the 30 nm Chromatin Fiber.” Journal of Molecular Biology 284 (1998): 71-84.
    Listed reading
  • Holley, W. R., I. S. Mian, S. J. Park, B. Rydberg, and A. Chatterjee. “A Model for Interphase Chromosomes and Evaluation of Radiation-Induced Aberrations.” Radiation Research 158 (2002): 568–580.
    Listed reading
  • Dikomey, E., J. Dahm-Daphi, I. Brammer, R. Martensen, and B. Kaina. “Correlation between Cellular Radiosensitivity and Non-repaired Double-strand Breaks Studied in Nine Mammalian Cell Lines.” International Journal of Radiation Biology 73, no. 3 (1998): 269-278.
    Listed reading
  • Löbrich, M., P. K. Cooper, and B. Rydberg. “Non-random Distribution of DNA Double-strand Breaks Induced by Particle Irradiation.” International Journal of Radiation Biology 70, no. 5 (1996): 493-503.
    Listed reading
  • The chapters in the table below are from: Hall, Eric J. Radiobiology for the Radiologist . 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 9780781726498.
    Listed reading
  • SES #: 2 · TOPICS: Radiation Interactions · READINGS: Chapter 1
    Reading assignment
  • SES #: 4 · TOPICS: Radiation Chemistry/LET/Tracks · READINGS: Chapter 7
    Reading assignment
  • SES #: 5 · TOPICS: Effects on Chromosomes/DNA · READINGS: Chapter 2
    Reading assignment
  • SES #: 6 · TOPICS: Dose Response in Vitro: Cell Survival Curves · READINGS: Chapter 3
    Reading assignment
  • SES #: 9 · TOPICS: Dose Response in Vivo · READINGS: Chapters 18 and 20
    Reading assignment
  • SES #: 10 · TOPICS: Chemical Modification of Radiation Response · READINGS: Chapters 6, 9 and 25
    Reading assignment
  • SES #: 11 · TOPICS: Cell, Tissue and Tumor Kinetics · READINGS: Chapters 4 and 5
    Reading assignment
  • SES #: 13 · TOPICS: Radiation Therapy: Tumor Radiobiology · READINGS: Chapter 21
    Reading assignment
  • SES #: 14 · TOPICS: Radiation Therapy (contd.): Fractionation · READINGS: Chapter 19
    Reading assignment
  • SES #: 15 · TOPICS: Acute Effects of Whole Body Exposure · READINGS: Chapter 8
    Reading assignment
  • SES #: 16 · TOPICS: Late Effects: Chronic Exposure/Low Doses · READINGS: Chapters 10, 11 and 12
    Reading assignment
  • SES #: 17 · TOPICS: Radiation Protection/Background Radiation/Radon · READINGS: Chapter 15
    Reading assignment
  • SES #: 21 · TOPICS: BNCT/Other Modalities · READINGS: Chapters 24, 27 and 28
    Reading assignment
  • Hall, Eric J. Radiobiology for the Radiologist . 5th ed. Philadelphia: Lippincott Williams & Wilkins, 2000. ISBN: 0781726429.
    Listed reading
  • Turner, J. E. Atoms, Radiation, and Radiation Protection. 2nd ed. New York: J. Wiley, 1995. ISBN: 9780471595816.
    Listed reading
  • Tubiana, M., J. Dutreix, and A. Wambersie. Introduction to Radiobiology. London, New York, Philadelphia: Taylor and Francis, 1990. ISBN: 9780850667455.
    Listed reading
  • Alpen, Edward L. Radiation Biophysics . 2nd ed. San Diego: Academic Press, 1998. ISBN: 9780120530854.
    Listed reading
  • Lodish, Berk, Zipursky, Matsudaira, Baltimore, and Darnell. Molecular Cell Biology. 4th ed. New York: W.H. Freeman and Company, 2003. ISBN: 9780716743668.
    Listed reading

Prerequisites & course information

Same subject as 22.55[J] Subject meets with 22.055 Prereq: Permission of instructor Acad Year 2027-2028: G (Fall) Acad Year 2028-2029: Not offered 3-0-9 units

Sources