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HST.584

Magnetic Resonance Analytic, Biochemical, and Imaging Techniques

3-0-12 units · Graduate

Introduction to basic NMR theory. Examples of biochemical data obtained using NMR summarized along with other related experiments. Detailed study of NMR imaging techniques includes discussions of basic cross-sectional image reconstruction, image contrast, flow and real-time imaging, and hardware design considerations. Exposure to laboratory NMR spectroscopic and imaging equipment included.

Spring 2006

Topics

  • Errors in Imaging (Ghosting)
  • MRI Hardware Overview
  • Class Presentations

Readings

  • Bernstein, Matt A., Kevin F. King, and Xiaohong Joe Zhou. Handbook of MRI Pulse Sequences . Boston, MA: Academic Press, 2004. ISBN: 9780120928613. Good reference on wide range of MRI topics.
    Listed reading
  • Hore, P. J. Nuclear Magnetic Resonance . New York, NY: Oxford University Press, 1995. ISBN: 9780198556824. Good introduction to NMR phenomenon and easy to read.
    Listed reading
  • Hore, P. J., J. A. Jones, and S. Wimperis. NMR: The Toolkit . New York, NY: Oxford University Press, 2000. ISBN: 9780198504153. Covers spectroscopy mostly.
    Listed reading
  • Abragam, A. The Principles of Nuclear Magnetism . New York, NY: Oxford University Press, 1983. ISBN: 9780198520146. A classic, but very dense and not all that easy to read.
    Listed reading
  • Slichter, C. P. Principles of Magnetic Resonance . 3rd ed. New York, NY: Springer-Verlag, 1992. ISBN: 9780387501574. Also a classic, a bit easier to read than Abragam.
    Listed reading
  • Bloembergen, N., E. M. Purcell, and R. V. Pound. “Relaxation Effects in Nuclear Magnetic Resonance Absorption.” Physical Review 73 (1948): 679-712. A classic relaxation paper.
    Listed reading
  • Hahn, E. L. “Spin Echos.” Physical Review 80 (1950): 580-594. The first paper to describe the spin echo phenomenon.
    Listed reading
  • Wedeen, V. J., P. Hagmann, W. Y. Tseng, T. G. Reese, and R. M. Weisskoff. “Mapping complex tissue architecture with diffusion spectrum magnetic resonance imaging.” Magnetic Resonance in Medicine 54 (2005): 1377-86.
    Listed reading
  • Savoy, R. L. “History and future directions of human brain mapping and functional neuroimaging.” Acta Psychologica 107 (2001): 9-42.
    Listed reading
  • Savoy, R. L. “Functional Magnetic Resonance Imaging (fMRI).” Encyclopedia of Neuroscience . 2nd ed. Boston, MA: Birkhauser, 1996.
    Listed reading
  • Savoy, Robert L. “Experimental design in brain activation MRI: Cautionary tales.” Brain Research Bulletin 67 (2005): 361–367.
    Listed reading
  • Savoy, Robert L. “Using Small Numbers of Subjects in fMRI-Based Research.” IEEE Engineering in Medicine and Biology Magazine 25 (2006): 52-59.
    Listed reading
  • Lecture notes, journal articles and book chapters will be handed out in class to supplement the class lectures.
    Listed reading

Prerequisites & course information

Same subject as 22.561[J] Prereq: Permission of instructor Acad Year 2027-2028: Not offered Acad Year 2028-2029: G (Spring) 3-0-12 units

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