HST.721
The Peripheral Auditory System
Fall 2005
Topics
- Lecture: Introduction
- Lecture: Anatomy
- Laboratory: Anatomy
- Lecture: Stria and EP
- Discussion: Anatomy
- Lecture: Hair Cells
- Discussion: Hair Cells and Transduction
- Lecture: Electromotility OHCs, Tuning and Mechanics
- Recitation: Problem Set 1
- Discussion: Stria and Endocochlear Potential
- Lecture: Afferent Transmission
- Discussion: Electromotility and OHCs
- Recitation: Problem Set 2
- Discussion: Tuning and Mechanics
- Lecture: Auditory Nerve Response
- Discussion: Afferent Transmission
- Lecture: ABRs and OAEs
- Recitation: Problem Set 3
- Discussion: Auditory Nerve Response
- Laboratory: Mouse Hearing
- Lecture: Efferent Control
- Discussion: Mouse Lab
- Lecture: Development
- Discussion: Efferent Control
- Lecture: Trauma and Repair
- Recitation: Problem Set 4
- Discussion: Inner Ear Development
- Discussion: Trauma and Repair
- Lecture: Sensorineural Hearing Loss
- Recitation: Problem Set 5
- Discussion: Sensorineural Hearing Loss
- Discussion: Review
- Recitation: Problem Set 6
Readings
- Geisler, C. Daniel. From Sound to Synapse: Physiology of the Mammalian Ear . New York, NY: Oxford University Press, 1998. ISBN: 9780195100259.
- Alberts, Bruce, et al. Molecular Biology of the Cell . 4th ed. New York, NY: Garland Science, 2002. ISBN: 9780815332183.
- Kikuchi, T., R. S. Kimura, D. L. Paul, and J. C. Adams. “Gap junctions in the rat cochlea: immunhistochemical and ultrastructural analysis.” Anat Embryol 191 (1995): 101-118.
- Liberman, M. C. “Morphological differences among radial afferent fibers in the cat cochlea: An electron-microscopic study of serial sections.” Hear Res 3 (1980): 45-63.
- ———. “Single-neuron labeling in the cat auditory nerve.” Science 216 (1982): 1239-1241.
- Corey, D. P., and A. J. Hudspeth. “Kinetics of the receptor current in bullfrog saccular hair cells.” J Neurosci 3 (1983): 962-976.
- Pickles, J. O., S. D. Comis, and M. P. Osborne. “Cross-links between stereocilia in the guinea pig organ of Corti, and their possible relation to sensory transduction.” Hear Res 15 (1984): 103-112.
- Denk, W., J. R. Holt, G. M. Shepherd, and D. P. Corey. “Calcium imaging of single stereocilia in hair cells: localization of transduction channels at both ends of tip links.” Neuron 15 (1995): 1311-1321.
- Salt, A. N., I. Melichar, and R. Thalmann. “Mechanisms of endocochlear potential generation by stria vascularis.” Laryngoscope 97 (1987): 984-991.
- Takeuchi, S., M. Ando, and A. Kakigi. “Mechanism generating endocochlear potential: role played by intermediate cells in stria vascularis.” Biophys J 79 (2000): 2572-2582.
- Holley, M. C., and J. F. Ashmore. “On the mechanism of a high-frequency force generator in outer hair cells isolated from the guinea pig cochlea.” Proc R Soc Lond B Biol Sci 232 (1988): 413-429.
- Hallworth, R., B. N. Evans, and P. Dallos. “The location and mechanism of electromotility in guinea pig outer hair cells.” J Neurophysiol 70 (1993): 549-558.
- Zheng, J., W. Shen, D. Z. He, K. B. Long, L. D. Madison, and P. Dallos. “Prestin is the motor protein of cochlear outer hair cells.” Nature 405 (2000): 149-155.
- Wilson, J. P., and J. R. Johnstone. “Basilar membrane and middle-ear vibration in guinea pig measured by capacitive probe.” J Acoust Soc Am 57 (1975): 705-723.
- Ruggero, M. A., and N. C. Rich. “Furosemide alters organ of Corti mechanics: Evidence for feedback of outer hair cells upon the basilar membrane.” J Neurosci 11 (1991): 1057-1067.
- Neely, S. T. “A model of cochlear mechanics with outer hair cell motility.” J Acoust Soc Amer 94, no. 1 (1993): 137-146.
- Richards, Griesinger, and Ashmore. “Fast vesicle replenishment allows indefatigable signaling at the first auditory synapse.” Nature 435 (2005): 212-215.
- Moser, T., and D. Beutner. “Kinetics of exocytosis and endocytosis at the cochlear inner hair cell afferent synapse of the mouse.” Proc Nat Acad Sci 97 (2000): 883-888.
- Glowatzki, E., and P. A. Fuchs. “Transmitter release at the hair cell ribbon synapse.” Nat Neurosci 5 (2002): 147-154.
- Liberman, M. C. “Auditory-nerve response from cats raised in a low-noise chamber.” J Acoust Soc Am 63 (1978): 442-455.
- Sachs, M. B., and E. D. Young. “Encoding of steady-state vowels in the auditory nerve: representation in terms of discharge rate.” J Acoust Soc Am 66 (1979): 470-479.
- Young, E. D., and M. B. Sachs. “Representation of steady state vowels in the temporal aspects of the discharge patterns of populations of auditory nerve fibers.” J Acoust Soc Amer 66 (1979): 1381-1403.
- Elgoyhen, A. B., D. S. Johnson, J. Boulter, D. E. Vetter, and S. Heinemann. “Alpha 9: An acetylcholine receptor with novel pharmacological properties expressed in rat cochlear hair cells.” Cell 79 (1979): 705-715.
- Russell, I. J., and E. Murugasu. “Medial efferent inhibition suppresses basilar membrane responses to near characteristic frequency tones of moderate to high intensities.” J Acoust Soc Am 102 (1997): 1734-1738.
- Maison, S. F., and M. C. Liberman. “Predicting vulnerability to acoustic injury with a non-invasive assay of olivocochlear reflex strength.” J Neuroscience 20 (2000): 4701-4707.
- Torres, M., and F. Giraldez. “The development of the vertebrate ear.” Mechanisms of Development 71 (1998): 5-21.
- Groves, A. K. and M. Bronner-Fraser. “Competence, specification and commitment in otic placode induction.” Development 127 (2000): 3489-3499.
- Eddison, M., I. Le Roux, and J. Lewis. “Notch signaling in the development of the inner ear: lessons from Drosophila.” Proc Natl Acad Sci U.S.A. 97 (2000): 11692-11699.
- Wang, Y., K. Hirose, and M. C. Liberman. “Dynamics of noise-induced cellular injury and repair in the mouse cochlea.” J Assoc Res Otolaryngol 3 (2002): 248-268.
- Izumikawa, M., R. Minoda, K. Kawamoto, K. A. Abrashkin, D. L. Swiderski, D. F. Dolan, D. E. Brough, and Y. Raphael. “Auditory hair cell replacement and hearing improvement by Atoh1 gene therapy in deaf mammals.” Nat Med 11, no. 3 (March 2005): 271-6. (Epub - February 13, 2005.)
- Liberman, M. C., and L. W. Dodds. “Single-neuron labeling and chronic cochlear pathology, III: Stereocilia damage and alterations of threshold tuning curves.” Hearing Research 16 (1984): 55-74.
- Heinz, M. G., and E. D. Young. “Response Growth With Sound Level in Auditory-Nerve Fibers After Noise-Induced Hearing Loss.” J Neurophysiology 91 (2004): 784-795.
- Moore, B. C., D. A. Vickers, C. J. Plack, and A. J. Oxenham. “Inter-relationship between different psychoacoustic measures assumed to be related to the cochlear active mechanism.” J Acoust Soc Amer 106, no. 5 (1999): 2761-2778.
Sources
- Course catalogue ↗Historical OpenCourseWare
- MIT OCW calendar ↗
- MIT OCW syllabus ↗
- MIT OCW readings ↗
- Historical MIT OpenCourseWare offering. Named reading entries and schedule topics are automatically extracted from the linked source pages.