Molecular Cell Biology

(3-4 Credit Hours) · Undergraduate

CELB 20040 Cell and Molecular Biology 1 - Principles at UCD; The structure and function of cells underlies our understanding of many areas of biology, including human health, plant science and environmental science. The module covers the principles of cell theory and the basic structure of prokaryotic and eukaryotic cells. Lectures will introduce the key molecules involved in maintaining cell function, and the pathways and processes to which they contribute. This module explores fundamental cellular features such as energy provision, compartmentation, membrane function, protein synthesis and folding, cell communication, and transport pathways between distinct subcellular locations. In addition, the module will address signal transduction, cell division, cell death mechanisms, and how these contribute to diseases such as cancer. Due consideration will be given to the general structure and arrangement of organelles of the endomembrane system, plastids, macromolecular machines, the extracellular matrix and the cytoskeleton, in addition to the molecules associated with each of these. Associated laboratory classes will complement the lectures, and will provide experience of observing cells, visualising subcellular components and making relevant interpretations. When taught at Perth, Australia: Taught as SCIE1106 - 'Molecular Biology of the Cell'. This is an introductory unit that explores prokaryotic and eukaryotic cell structure and function at the physiological and molecular levels. A strong emphasis is placed on applications in biomedicine and biotechnology. The unit builds on concepts introduced in BIOL1130 Frontiers in Biology (formerly BIOL1130 Core Concepts in Biology) and ANHB1101 Human Biology I: Becoming Human. The first part of the unit covers DNA, RNA and protein structure; DNA replication; gene expression and its regulation; and recombinant DNA technology. The second part of the unit deals with the cell cycle and cell differentiation; cell structure and compartmentation; the structure of biological membranes and strategies used to move molecules across these membranes; and intercellular communication. Applications of cell and molecular biology in microbiology, disease diagnosis and therapy, and genetic engineering are discussed in the final part of the unit. Practical classes illustrate fundamental techniques in cell and molecular biology, and tutorials discuss recent advances in microbiology, physiology and biochemistry.