Oncobiology

(2 Credit Hours) · Undergraduate

Definition and pathology of cancer cells: benign, premalignant and malignant tumors. Grading and staging. Carcinogenesis as a multistep process, chemical carcinogens, irradiation, viral carcinogenesis etc.. Cancer and the host: heredity of cancer, immunology of cancer, cachexia. Growth mechanisms of cancer cells: cytokines and receptors, signal transduction mechanisms, oncogenes, tumorsuppressor genes, the cell cycle, apoptosis, angiogenesis, telomerase, adhesion and metastasis, multidrug resistance etc.. Molecular techniques for diagnosis of cancer and minimal residual disease. Principles of cancer treatment: irradiation, chemotherapy, gene therapy, humoral and cellular immunotherapy, tumor vaccination, cytokines, anti-angiogenesis etc.