3D Genome Regulation

(4 Credits)

A fundamental question in biology is how gene expression is regulated during development and differentiation. The way genes are expressed is intimately connected to ways in which the genome is organized in the 3D nucleus. Understanding 3D genome organization is now becoming possible thanks to chromosome conformation capture technologies combined with nucleic acid sequencing, proteomics, bioinformatics, advanced imaging, and molecular genetic techniques. These approaches are providing unprecedented insight into genetic and epigenetic mechanisms that regulate gene expression programs. Through an inquiry-based approach we will examine scientific discoveries and research publications on 3D genome regulation during development, differentiation, and disease.