Techniques in Structural Biology and Molecular Biophysics

(2 Credits)

This course teaches students the underlying theory and techniques used in X-ray crystallography, electron microscopy, NMR spectroscopy, mass spectrometry, and computer modeling. The information in this course enables students to pursue their dissertation research in structural biology. Topics include X-ray diffraction, phasing, and refinement; cryoelectron microscopy, image processing, and tomography; multidimensional NMR spectroscopy; MALDI-TOF and Q-TOF mass spectrometry; and ab initio and homology modeling of proteins.