Principles of Genome Engineering

1 Course Unit

This course provides a comprehensive overview of modern genomics and genome engineering techniques and their applications in basic research and translational medicine. Both classical DNA recombination techniques and CRISPR-mediated genome editing will be discussed. The genomics section will explore next- and third- generation sequencing methods and their applications like RNA-seq and ChIP-seq. Additionally, students will gain hands-on experience with commonly used tools for designing genome editing experiments and analyzing genomics data. Key concepts in genomics and gene regulation will be introduced, with practical examples from development, stem cells, disease models, and synthetic biology, highlighting how engineering techniques transform and advance these fields. Spring 1 Course Unit