Principles of Chemical Reactivity

Supplemental texts: Clayden, Greeves and Warren, Organic Chemistry, 2nd edition, Oxford University Press; Atkins, de Paula and Keeler, Atkins’ Physical Chemistry, 11th edition, Oxford University Press. Recommended readings accompany the outline. Supplemental Clayden chapters: 1, 2, 4, 5 and 8. Useful resources: https://mechanisms.edu.rsc.org/ and http://www.chemtube3d.com/.

Listed material: Organic Chemistry, Second Edition, Clayden, J.; Greeves, N.; Warren, S.

Listed material: Oxford University Press, New York, 2012 (Required Textbook).

Listed material: Atkins’ Physical Chemistry, Twelfth Edition, Atkins, P., De Paula, J., Keeler,

Listed material: J. Oxford University Press, New York, 2023 (Supplemental Textbook). Lectures:

Listed material: Success in the course will depend on thoughtful engagement with the textbook and assigned readings. By the end of the course, students will be able to analyze reaction pathways and anticipate the reactivity of common organic partners.

Supplemental: The following chapters are useful introductory and supplemental material for CHEM/ENCH-212. Organic Chemistry by Clayden, 2nd Edition

Supplemental: Chapter 1: What is organic chemistry? (an interesting read)

Supplemental: Chapter 2: Organic structures (Good for learning how to draw organic structures efficiently)

Supplemental: Chapter 4: Structure of molecules (useful for learning how atomic orbitals combine to form molecular orbitals)

Supplemental: Chapter 5: Organic reactions (very useful for understanding the art of curly arrow drawing)

Supplemental: Chapter 8: Acidity, basicity, and pKa (very good for understanding what pKa values indicate, as well as how to understand/predict how pKa values will change with the structure of a molecule) Useful Software: Free online testing and learning tools are available from the RSC website: http://www.rsc.org/learn- chemistry/mechanism-inspector/ Free online reaction animations (as well as orbitals animations) are available at the following website: http://www.chemtube3d.com/ Data processing associated with the laboratory component of the course will require the use of Microsoft Excel. Try to work through all the practice problems before attending the Tutorial.